Search for dissertations about: "RNA world"

Showing result 1 - 5 of 64 swedish dissertations containing the words RNA world.

  2. 1. Versatile and Antique World of RNA : The Simplicity of RNA Mediated Catalysis

    Author : Ema Kikovska; Leif Kirsebom; Venkat Gopalan; Uppsala universitet; []
    Keywords : Microbiology; RNA Catalysis; RNase P; Metal ions; tRNA Processing; Ribozyme; Mikrobiologi;

    Abstract : RNA is the only biological molecule that can function both as a repository of information and as a catalyst. This, together with the ability to self-replicate, led to recognition of RNA as ‘prelude to life’.My work highlights some of the important features of RNA as a catalyst, exemplified by RNase P. READ MORE

  4. 2. The deep evolutionary roots of non-coding RNA - a comparative genomics approach

    Author : Marc Patrick Hoeppner; Anthony M. Poole; Britt-Marie Sjöberg; Jürgen Brosius; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; non-coding RNA; evolution; comparative genomics; RNA world; introns; snoRNA; miRNA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Abstract : Non-coding RNAs (ncRNA) are a diverse group of genes that do not encode proteins but function exclusively on the level of RNA and were originally suggested to be remnants of a pre-DNA stage of life known as the RNA world. More recent work, however, has uncovered a rich repertoire of previously unknown families with possible consequences for our understanding of the origin and evolution of the modern RNA infrastructure. READ MORE

  5. 3. Hidden patterns that matter : statistical methods for analysis of DNA and RNA data

    Author : Therese Kellgren; Patrik Rydén; Sara Sjöstedt de Luna; Rebecka Jörnsten; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome; Next-generation sequence; statistics; microarrays; bacteria; antibiotic resistance; inherited diseases; Co-expression networks; centralization within subgroups;

    Abstract : Understanding how the genetic variations can affect characteristics and function of organisms can help researchers and medical doctors to detect genetic alterations that cause disease and reveal genes that causes antibiotic resistance. The opportunities and progress associated with such data come however with challenges related to statistical analysis. READ MORE

  6. 4. Connecting Systemic RNAi to the Endomembrane System in Caenorhabditis elegans

    Author : Benjamin T. Holmgren; Andrea Hinas; Gerhart Wagner; Peter Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Systemic RNAi; RNAi inheritance; Endomembrane system; Late endosome; SID-5; SEC-22; SYX-6; C12D8.1; RNA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : RNA interference (RNAi) is a gene regulation mechanism conserved among eukaryotes. To silence gene expression, RNAi relies on a short single-stranded guide RNA to steer the RNA-induced Silencing Complex (RISC) to mRNAs with guide strand-complementary sequences. RNAi is a highly membrane-associated process. READ MORE

  7. 5. Inference of Hierarchical Structure in Complex Systems

    Author : Olof Görnerup; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Substitution groups; Modularity; Hierarchical dynamics; RNA world; Genetic code; Aggregation; Primordial evolution; Molecular evolution; Model reduction; Self-organization; Lumping; Emergence; Coarse graining;

    Abstract : Hierarchical organization is a central property of complex systems. It is even argued that a system is required to be hierarchical in order to evolve complexity within reasonable time. A hierarchy of a system is defined as the set of self-contained levels at which the system operates and can be described on. READ MORE