Search for dissertations about: "RNA"

Showing result 16 - 20 of 1583 swedish dissertations containing the word RNA.

  2. 16. Development and application of spatial transcriptomics methods

    Author : Zaneta Andrusivova; Joakim Lundeberg; Jay W. Shin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA; Spatial Transcriptomics; RNA sequencing; Biotechnology; Bioteknologi;

    Abstract : Transcriptomics is one of the pivotal fields in molecular biology, enabling comprehensive analysis of gene expression patterns. Recent advancements in the biotechnology field have transformed the transcriptomics research, providing insights into the complexity of cellular processes in a greater detail. READ MORE

  4. 17. A-to-I RNA editing : Function and consequences during brain development

    Author : Ylva Ekdahl; Marie Öhman; Kazuko Nishikura; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNA editing; miRNAs; Brain development; Molecular Biology; molekylärbiologi;

    Abstract : The aim of my thesis has been to study how A-to-I RNA editing of miRNAs is regulated during brain development and the biological function of these editing events.Using high throughput RNA sequencing, we performed an unbiased search for edited, mature miRNAs in total mouse brain tissue from three developmental stages. READ MORE

  5. 18. The Spatial Context – through the lens of method development

    Author : Linda Kvastad; Joakim Lundeberg; Lars Feuk; KTH; []
    Keywords : RNA; RNA-sequencing; transcriptomics; spatial transcriptomics; single cells; pediatric brain tumors; Spatial RIN; Bioteknologi; Biotechnology;

    Abstract : In the present moment of time, we find ourselves in a period where the advancement of genomic tools is progressing at a fast pace. Of particular interest for this thesis is the study of gene activity. READ MORE

  6. 19. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Author : Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Keywords : RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Bioteknologi; Biotechnology;

    Abstract : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. READ MORE

  7. 20. Epigenetic Regulation by Noncoding RNA

    Author : Tanmoy Mondal; Chandrasekhar Kanduri; Jérôme Cavaillé; Uppsala universitet; []
    Keywords : Genomic Imprinting; Noncoding RNA; Epigenetics; DNA methylation; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. READ MORE