Search for dissertations about: "RNP"
Showing result 1 - 5 of 23 swedish dissertations containing the word RNP.
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1. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases
Abstract : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. READ MORE
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2. Transcription and transport of a messenger RNP particle : novel regulatory mechanisms
Abstract : In all living cells gene expression is a central process that involves several steps, including transcription, processing, transport and translation. A fine-tuning of these events is a pre-requisite for proper cellular function. READ MORE
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3. Assembly and transport of messenger and ribosomal RNP particles in the dipteran Chironomus tentans
Abstract : Gene expression in eukaryotic organisms commences with the synthesis of a precursor RNA, which has to be extensively processed to yield a mature RNA molecule. In addition to processing, the RNA molecule needs to associate with a proper set of proteins. READ MORE
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4. Autoantibodies in healthy blood donors, rheumatic and autoimmune liver diseases
Abstract : Autoimmunity is a common phenomenon where the immune system recognises the body's own tissues. Autoimmunity can lead to disease if tissue damage occurs. Autoimmune diseases affect 5–10% of the global population and in many of these autoantibodies can be detected. The autoantibodies can be detected with several different methods. READ MORE
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5. Investigation of RNase P active site residues and catalytic domain interaction
Abstract : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. READ MORE