Search for dissertations about: "RPE"

Showing result 1 - 5 of 32 swedish dissertations containing the word RPE.

2. 1. Interactions between neural retina, retinal epithelium and choroid

   Author : Lena Ivert; Karolinska Institutet; Karolinska Institutet; []
   Keywords : RPE; neural retina; basal lamina; Bruch s membrane; choroid; subretinal space; bleb detachment; ICG; FAG; SLO; choroidal blood flow.;

   Abstract : The retinal pigment epithelium (RPE) is a non-replicating monolayer that plays a key role nursing the photoreceptors of the neural retina, regulating fluid movement within the subretinal space, maintaining a basal laminar layer of Bruch s membrane, and influencing the choriocapillaris. This project investigates how surgical manipulation of the retinal epithelial layer influences the neural retina, the choroid and the epithelial layer itself. READ MORE

4. 2. Choroidal neovascularization (CNV) : clinical and experimental aspects

   Author : Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

   Abstract : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. READ MORE

5. 3. Retinal pigment epithelial cells, oxidative stress and lipofuscin : relation to age-related macular degeneration

   Author : Staffan Sundelin; Stefan Seregard; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : In developed countries, age-related macular degeneration (AMD) is the most common cause of loss of central vision in people over the age of 65. The retinal pigment epithelium (RPE) appears to be the site of early pathological changes in AMD. READ MORE

6. 4. Experimental transplantation of retinal and iris pigment epithelial cells into the subretinal space

   Author : Sven Crafoord; Jan Ulrik Prause; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : A dysfunction of the retinal pigment epithelium (RPE) is the main cause for the development of age-related macular degeneration (ARMD) and visual loss in elderly people. For about 10 years experimental and clinical attempts to transplant RPE cells have been performed. READ MORE

7. 5. Human embryonic stem cells for retinal repair : preclinical in vitro and in vivo studies for the treatment of age-related macular degeneration with human embryonic stem cell-derived retinal pigment epithelial cells

   Author : Sandra Petrus-Reurer; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Age-related macular degeneration (AMD) is the major cause of vision loss in the industrialized countries in people above sixty years of age. The dry advanced form of the disease, also termed as geographic atrophy (GA), is characterized by the progressive death of retinal pigment epithelial cells (RPE) and consequent loss of the adjacent photoreceptor (PR) layer, leading to an impaired visual function. READ MORE