Search for dissertations about: "Radioligand"

Showing result 1 - 5 of 75 swedish dissertations containing the word Radioligand.

  2. 1. Synthesis and evaluation of new PET radioloigands for imaging central norepinephrine transporters

    Author : Magnus Schou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; NET; Brain;

    Abstract : The noradrenergic (NE), serotonergic (5-HT) and dopaminergic (DA) neurotransmission systems all have specific proteins responsible for the regulation of synaptic concentrations of neurotransmitter in the central nervous system (CNS) and in the periphery. Several reports have shown that the expression of these proteins, the monoamine transporters, within the CNS, may be altered in patients with certain neurodegenerative or neuropsychiatric disorders. READ MORE

  4. 2. Development of radioligands for the serotonergic neurotransmission system for use in positron emission tomography

    Author : Johan Sandell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; Brain; 5-HT1A receptor; serotonin transporter;

    Abstract : The serotonergic system is implicated in several neuropsychiatric disorders, such as depression, anxiety and schizophrenia. Several hypotheses on the pathophysiology of these disorders are based on the pharmacology of serotonergic drugs. Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression and anxiety. READ MORE

  5. 3. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

    Author : Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

    Abstract : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. READ MORE

  6. 4. Catecholaminergic neurotransmission in heart and brain : development of tracers for positron emission tomography

    Author : Claus Oliver Langer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; Catecholamine; Norepinephrine; Dopamine; Heart; Brain; Metaraminol; Dopamine D2 Receptor;

    Abstract : The catecholamines norepinephrine and its biosynthetic precursor dopamine are two principal neurotransmitters in the human central nervous system (CNS). Moreover, norepinephrine is a major transmitter substance in the peripheral, autonomic nervous system. READ MORE

  7. 5. Dopamine D2 receptor G protein coupling and it's regulation

    Author : Anton Terasmaa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dopamine; D2 receptor; G protein; supersensitivity; 6-hydroxydopamine; [3 S]GTP-gamma-S; radioligand binding;

    Abstract : Dopamine (DA) receptors belong to the superfamily of G protein coupled receptors. The D2 DA receptor is negatively coupled with adenylate cyclase via pertussis toxin sensitive (Gi/o) G proteins. READ MORE