Search for dissertations about: "Rapid absorption"

Showing result 1 - 5 of 95 swedish dissertations containing the words Rapid absorption.

2. 1. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties

   Author : Ann Tronde; Gerrit Borchard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; lung; pulmonary; drug delivery; inhalation; drug transport; pharmacokinetics; absorption; bioavailability; drug metabolism; preclinical; rat; in vivo; isolated and perfused lung; Caco-2; nebulization catheter; aerosol; physicochemical; peptide; efflux; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE

4. 2. Deposition and absorption of inhaled drugs

   Author : Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Abstract : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. READ MORE

5. 3. New Concepts in Administration of Drugs in Tablet Form : Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System

   Author : Susanne Bredenberg; Christer Nyström; Carla Caramella; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Interactive mixture; Dose homogeneity; Disintegration; Bioadhesion; Oromucosal delivery; Sublingual tablet; Rapid absorption; Individual dosage; Drug dispensing device; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

   Abstract : This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. READ MORE

6. 4. Absorbent Materials from Kraft Pulp

   Author : Fredrik Wernersson Brodin; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; retention; MFC; oxidation; Absorbent; absorption; TEMPO; freeze drying; disintegration;

   Abstract : SuperAbsorbent Polymers (SAPs) have, since being introduced in the 1980s, become an important constituent in hygiene products, such as disposable diapers. The design of disposable diapers has changed over the years and today thinner products can be produced partly because of the excellent absorption and retention properties of the petrochemical-based SAPs. READ MORE

7. 5. Absorbent Materials from Kraft Pulp

   Author : Fredrik Wernersson Brodin; Chalmers tekniska högskola; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MFC; retention; foam; TEMPO oxidation.; absorption; Absorbent;

   Abstract : Superabsorbent polymers (SAP) have, since being introduced in the 1980s, become an important constituent in hygiene products, such as disposable diapers. The design of disposable diapers has changed over the years and today thinner products can be produced partly because of the excellent absorption and retention properties of the petrochemical-based SAP. READ MORE