Search for dissertations about: "Rat neocortex"

Showing result 6 - 10 of 11 swedish dissertations containing the words Rat neocortex.

  2. 6. Development of positron emission tomography radioligands for the dopaminergic and serotonergic neurotransmission systems

    Author : Camilla Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : PET; Radioligand; Dopamine transporter; Serotonin transporter; 5-HT1A receptor; 5-HT2A receptor;

    Abstract : The dopaminergic and serotonergic neurotransmission systems are of central interest in relation to several neuropsychiatric disorders. The main objectives were to develop new suitable radioligands for positron emission tomography (PET) examinations of the dopamine transporter (DAT) as well as the serotonin 5-HT1A and 5-HT2A-receptors. READ MORE

  4. 7. Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies

    Author : Daniela Papadia; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The brain can be described as a complex network and its functioning depends on an efficient communication between all its components. Large-scale communication is made possible by neuronal-network oscillations. READ MORE

  5. 8. Regulation of postnatal neurogenesis and brain angiogenesis by thyroid hormone

    Author : Jenny Liqun Zhang; Göteborgs universitet; []
    Keywords : thyroid hormone; neurogenesis; angiogenesis; SVZ OB; hippocampus; neural stem cells; endothelial cells; astrocytes;

    Abstract : Thyroid hormone (TH), which is secreted by the thyroid gland, exerts significant effects on the central nervous system (CNS), especially during development, so that delayed treatment of perinatal hypothyroidism results in severe cognitive retardation. Continuous postnatal neurogenesis occurs throughout adulthood in the subventricular zone (SVZ) of the lateral ventricle wall and in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampal formation. READ MORE

  6. 9. Conductance-based principles of neuronal firing and excitability

    Author : Hugo Zeberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The brain is an electrical organ whose activity is determined by the flow of ions across cell membranes. As such, the conductances that control the ion flux is a key to our understanding of the nervous system. Neurons process information by their ability to rapidly depolarize and fire action potentials. READ MORE

  7. 10. PET studies of the serotonin transporter in the human brain

    Author : Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

    Abstract : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. READ MORE