Search for dissertations about: "Recombinant antibody microarray"

Showing result 1 - 5 of 14 swedish dissertations containing the words Recombinant antibody microarray.

2. 1. Design of recombinant antibody microarrays for global proteome analysis

   Author : Johan Ingvarsson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioteknik; oncoproteomics; Recombinant antibody microarray; scFv; Biotechnology; plasma proteome analysis;

   Abstract : Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recombinant scFv antibody fragments for large-scale comprehensive proteome analysis. READ MORE

4. 2. Protein Microarrays Based on Single Framework Recombinant Antibody Fragments (SINFABS) - Catcher and Carrier - A Crucial Combination

   Author : Cornelia Steinhauer; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; probe; coupling chemistry; solid support; stability; scFv; antibody microarray; protein microarray; Biotechnology; Bioteknik;

   Abstract : Antibody-based microarrays are among the novel class of rapidly evolving proteomic technologies. In recent years, antibody microarrays have emerged as a unique tool for high-throughput protein expression profiling with great promise within biomedicine and a wide range of potential applications, including disease diagnostics and biomarker discovery. READ MORE

5. 3. Strategies for Miniaturized Biomarker Detection

   Author : Belinda Adler; Avdelningen för Biomedicinsk teknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biomarker; miniturization; lab-on-a-chip; proteomics; PSA; microarray; mass spectrometry; MALDI MS; SPE; sample preparation; immunoaffinity; antibody; aptamer; mass tag; ISET.;

   Abstract : The aim of this thesis is development and application of different miniaturized strategies for detection of biomarkers. The biomarker PSA (prostate specific antigen), which is prostate cancer specific, has been the main focus of the thesis. READ MORE

6. 4. Design of antibody microarrays for global profiling of membrane proteins and soluble proteins

   Author : Linda Dexlin Mellby; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scFv; membrane proteins; proteomics; protein chip; recombinant antibodies; Antibody microarray; protein profiling; membrane proteomics;

   Abstract : Antibody-based microarrays have emerged as an established proteomic technology allowing multiplexed and sensitive profiling of complex proteomes, in a high-throughput and miniaturized manner. Recently, numerous applicative efforts have been pursued generating disease-associated protein signatures that now could be further explored for improved disease diagnostics, prognostics and classification. READ MORE

7. 5. Tailoring of Antibody Arrays - Technical Advances Towards Global Proteome Analysis

   Author : Linn Petersson; Institutionen för immunteknologi; []
   Keywords : antibody arrays; recombinant antibodies; scFv; miniaturization of arrays; immobilization of scFv; global proteome analysis; biomarker discovery;

   Abstract : Abstract The number of cancer and autoimmune disease diagnoses increases in our society, which place high demands on the health care system. Being able to tailor treatments for each individual patient is called "Personalized medicine", and could revolutionize the care in the future. READ MORE