Search for dissertations about: "Regioselectivity"

Showing result 1 - 5 of 54 swedish dissertations containing the word Regioselectivity.

  2. 1. Ligand Dependent Regioselectivity in Palladium Mediated Allylic Alkylation

    Author : Charlotte Johansson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Palladium; allylic alkylation; η3-allyl palladium complexes; regioselectivity; PN-ligand; memory effects; dynamics; ligand effect; trans effects.;

    Abstract : In this thesis, different aspects on ligand dependent regioselectivity in palladium mediated allylic alkylation have been studied. It is believed that the regioselectivity is a result of nucleophilic attack trans to phosphorous when applying ligands wih different donor atoms. READ MORE

  4. 2. Towards Understanding of Selectivity & Enantioconvergence of an Epoxide Hydrolase

    Author : Åsa Janfalk Carlsson; Mikael Widersten; Uwe T. Bornscheuer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Epoxide hydrolase; Epoxide; Enantioselectivity; Regioselectivity; Enantioconvergence; Crystal structures; Biocatalysis; Immobilization; Transient kinetics; CASTing; Directed evolution; Biokemi; Biochemistry;

    Abstract : Epoxide hydrolase I from Solanum tuberosum (StEH1) and isolated variants thereof has been studied for mapping structure-function relationships with the ultimate goal of being able to in silico predict modifications needed for a certain activity or selectivity. To solve this, directed evoultion using CASTing and an ISM approach was applied to improve selectivity towards either of the enantiomeric product diols from (2,3-epoxypropyl)benzene (1). READ MORE

  5. 3. Organic reactions in self-organized surfactant systems

    Author : Fredrik Currie; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic synthesis; kinetics; micelle; regioselectivity; microemulsion;

    Abstract : The aim of this work has been to investigate how microemulsions and micellar systems can be used as reaction media to overcome reactant incompatibility, enhance reaction rates and especially to control product composition, i.e., introducing regioselectivity, in organic synthesis. READ MORE

  6. 4. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

    Author : Peter Bach; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mGluR5; P2Y12; gastroesophageal reflux disease GERD ; thrombosis; ethyl nicotinates; ureas; sulfonylureas; oxazoles; bioisosteres; regioselectivity; solvent effect.;

    Abstract : The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was developed to investigate the structure-activity relationships (SAR) of a novel series of 2-alkynylpyridine derivatives as mGluR5 antagonists. READ MORE

  7. 5. Aspects on the Regio and Stereo Selectivity in the Hydrolsilylation of 1,3-Dienes

    Author : Magnus Gustafsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metallorganisk kemi; Organometallic chemistry; Organisk kemi; Organic chemistry; Lewis acid; electrophilic ring closure; asymmetric hydrosilylation; reaction conditions; isoprene; regioselectivity; oxygen; Wilkinsons catalyst; 15N-1H-HMQC; 31P; heterobidentate ligands; catalyst; palladium; epoxy-allylsilanes; rhodium complexes; dienes;

    Abstract : This thesis is a summary of four papers concerning various aspects on the transition metal catalysed hydrosilylation of 1,3-dienes. The hydrosilylation reaction is formally an addition of a hydrosilane to an unsaturated system and depending on the reaction conditions, control of stereo-, regio-, and chemo-selectivity can be achieved. READ MORE