Search for dissertations about: "Respiratory Deposition"

Showing result 1 - 5 of 36 swedish dissertations containing the words Respiratory Deposition.

2. 1. Deposition and absorption of inhaled drugs

   Author : Eva Bondesson; Malmö Klinisk fysiologi och nuklearmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; Clinical physics; technetium-99m; radionuclide imaging; radioactive aerosol; powder inhaler; pharmacokinetics; mucociliary clearance; lung deposition; gamma scintigraphy; inhalation; deposition modelling; drug absorption; absorption enhancer; aerosol; medicinsk instrumentering; Physiology; Fysiologi;

   Abstract : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. READ MORE

4. 2. Health-related aerosol particle studies, respiratory tract deposition and indoor source identification

   Author : Jakob Löndahl; Kärnfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; aerosol particle; health; ultrafine particles; nanoparticle; deposition; respiratory tract; Fysicumarkivet A:000;

   Abstract : Aerosol particles have, since Classical Antiquity, been linked to adverse effects on human health. It is estimated that the particles in urban air pollution causes 100 000 deaths in Europe each year, whereof 5 000 in Sweden. READ MORE

5. 3. Experimental Determination of the Deposition of Aerosol Particles in the Human Respiratory Tract

   Author : Jakob Löndahl; Kärnfysik; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; nanoparticles; deposition; respiratory tract; health; air pollution; aerosol particle; ultrafine particles; lung; Fysicumarkivet A:000;

   Abstract : BACKGROUND: Aerosol particles have, since the antiquity, been linked to adverse effects on human health. It is estimated that the particles in urban air pollution cause at least 100,000 deaths in Europe each year, whereof 5,000 in Sweden. READ MORE

6. 4. Diesel exhaust and wood smoke : mechanisms, inflammation and intervention

   Author : Ala Muala; Thomas Sandström; Mark W Frampton; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Air pollution; deposition; bronchoscopy; Immunohistochemstry; filter; NO bioavailability; lungmedicin; Lung Medicine;

   Abstract : Background Particulate matter (PM) air pollution is associated with increased respiratory and cardiovascular morbidity and mortality. Diesel engine exhaust (DE) and wood combustion are major contributors to ambient air pollution and adverse health effects. READ MORE

7. 5. Charting the human lung with inhaled nanoparticles : Development of AiDA - a new diagnostic technique for respiratory disease

   Author : Jonas Jakobsson; NanoLund: Centre for Nanoscience; []
   Keywords : Aerosol; lung; lung deposition; respiratory tract; nanoparticles; ultrafine particles; airspace dimension assessment; AiDA; Chronic obstructive pulmonary disease; COPD; lung morphology;

   Abstract : Changes to the smallest structures of the distal lung are often the first sign of severe respiratory disease, but to date methods to detect and quantify these changes are limited. Chronic obstructive pulmonary disease (COPD) is currently estimated to be the third most common cause of death worldwide, but is to a large extent under-diagnosed, especially at early stages. READ MORE