Search for dissertations about: "Reverse chemical genetics"
Found 4 swedish dissertations containing the words Reverse chemical genetics.
-
1. UDP-sugar metabolizing pyrophosphorylases in plants : formation of precursors for essential glycosylation-reactions
Abstract : UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. READ MORE
-
2. Functional genomics of vascular endothelial cells
Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. READ MORE
-
3. On angiogenesis modulation
Abstract : During evolution, the transition from unicellular to multicellular organisms required the origin of a transport system capable of interconnecting specialized cells throughout the body of the organism. In higher animals, this route of transportation is the cardiovascular system, which allows gas exchange, and transport of immune cells, hormones, macromolecules, nutrients and waste products. READ MORE
-
4. Mechanistic characterization of post-transcriptional gene silencing
Abstract : With the ongoing task of identifying and characterizing genes in the human genome, there is a great demand for tools to study these genes. Today, reverse genetics is the most effective way to explore gene function. This involves suppression of the gene of interest by a set of manipulation techniques. READ MORE