Search for dissertations about: "S-adenosyl-methionine"
Showing result 1 - 5 of 11 swedish dissertations containing the word S-adenosyl-methionine.
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1. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids
Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE
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2. Ribosomal RNA Modification Enzymes : Structural and functional studies of two methyltransferases for 23S rRNA modification in Escherichia coli
Abstract : Escherichia coli ribosomal RNA (rRNA) is post-transcriptionally modified by site-specific enzymes. The role of most modifications is not known and little is known about how these enzymes recognize their target substrates. READ MORE
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3. The Importance of Being Promiscuous : Understanding enzyme function, specificity, and evolution through structure
Abstract : Enzymes are known to be amazingly specific and efficient catalysts. However, many enzymes also have so-called promiscuous functions, i.e., they are able to catalyze other reactions than their main one. READ MORE
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4. To reduce a ribonucleotide – Radical solutions in enzymology in form and function
Abstract : It has been more than 50 years since the enzyme system ribonucleotide reductase (RNR), catalysing the reduction of ribonucleotides to deoxyribonucleotides, was first discovered. RNR was also the first time that radical chemistry was revealed in an enzyme. READ MORE
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5. Meticulous control of the T3SS of Yersinia is essential for full virulence
Abstract : The type III secretion system (T3SS) of pathogenic Yersinia pseudotuberculosis is involved in virulence. The syringe-like secretion system spans both bacterial membranes and is responsible for the ability of Yersinia to transfer toxic proteins (Yop proteins) into the eukaryotic target cell. READ MORE