Search for dissertations about: "SELF-TOLERANCE"

Showing result 1 - 5 of 38 swedish dissertations containing the word SELF-TOLERANCE.

  2. 1. Mercury-induced autoimmunity : Genetics and immunoregulation

    Author : Monika Hansson; Manuchehr Abedi-Valugerdi; Marita Troye-Blomberg; Lucette Pelletier; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mercury; autoimmunity; collagen-induced arthritis; Th1 Th2; silver; tight-skin 1 mice; Immunology; Immunologi;

    Abstract : The existence of immune self-tolerance allows the immune system to mount responses against infectious agents, but not against self-molecular constitutes. Although self-tolerance is a robust phenomenon, in some individuals as well as in experimental models, the self-tolerance breaks down and as a result, a self-destructive autoimmune disease emerges. READ MORE

  4. 2. Studies on the function of CD4CD25 regulatory T cells: An in vitro approach

    Author : Lukas Cederbom; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; CD152; Costimulation; Dendritic cells; Regulatory T cells; CD4 CD25 ; serology; transplantation; Immunologi; serologi;

    Abstract : Immunological self-tolerance is a state of the whole organism where deleterious responses are either avoided or regulated. Breaking of immunological tolerance will lead to autoimmune disease or chronic inflammatory conditions. READ MORE

  5. 3. The Genetics of Systemic Lupus Erythematosus : The Specificity of IRF5 to SLE

    Author : MV Prasad Linga Reddy; Marta Alarcön Riquelme; Dan Holmberg; Uppsala universitet; []
    Keywords : Molecular genetics; Systemic lupus erythematosus; Interferon regulatory factor 5; Transmission-Disequilibrium Test; Family-based association test; Linkage Disequilibrium; Hardy-Weinberg equilibrium; Genetik;

    Abstract : The breakdown of self-tolerance is the main driving force behind susceptibility to SLE. When this occurs, T and B cells are activated in an uncontrolled manner and produce autoantibodies against self fragmented DNA, RNA and sometimes other parts of the cell such as cardiolipin, phosphatidylserine, etc. READ MORE

  6. 4. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis

    Author : Julia Femel; Anna-Karin Olsson; Grietje (Ingrid) Molema; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor; therapeutic; cancer vaccine; angiogenesis; vasculature; fibronectin; galectin-1; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Science; Medicinsk vetenskap;

    Abstract : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. READ MORE

  7. 5. Genetic analysis of autoimmune diseases using animal models : Mapping susceptibility genes for multiple sclerosis and rheumatoid arthritis

    Author : Hai-Tao Yang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Collagen induced arthritis CIA ; Experimental allergic encephalomyelities EAE ; Multiple sclerosis MS ; Quantitative trait loci QTL ; Rheumatoid arthritis RA ; Linkage analysis; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Abstract : Autoimmune diseases such as rheumatoid arthritis and multiple sclerosis are common human diseasesaffecting 1% and 0.1% of the population respectively. These diseases are characterized by abnormal self-tolerance in the immune system and autoimmune reactions. READ MORE