Search for dissertations about: "SH-SY5Y cells"

Showing result 1 - 5 of 49 swedish dissertations containing the words SH-SY5Y cells.

  2. 1. Ras-MAPK signaling in differentiating SH-SY5Y human neuroblastoma cells

    Author : Anna-Karin Olsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Neuroblastoma; SH-SY5Y; differentiation; neurite; Ras; MAPK; PKC; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Neuroblastoma is a malignant childhood cancer, originating from sympathetic neuroblasts of the peripheral nervous system. Neuroblastoma is a heterogenous group of tumours, while some are highly malignant others can spontaneosly mature into a more benign form or regress. READ MORE

  4. 2. Neuroblastoma SH-SY5Y and neural progenitor C17.2 cell lines as models for neurotoxicological studies​

    Author : Jessica Lundqvist; Anna Forsby; Åsa Fex Svenningsen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; SH-SY5Y; C17.2; in vitro neurotoxicity; cell culture conditions; biomarkers; in vitro developmental neurotoxicity; whole genome microarray; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : We are surrounded by chemicals, thus understanding how exposure to these chemicals affect us during our life is of great social importance. In order to predict human acute toxicity of chemicals, cosmetics or drugs, development of novel in vitro test strategies is required. READ MORE

  5. 3. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells

    Author : Dina Popova; Jacobsson Stig O.P.; Anna Forsby; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxicity; Neuronal cell culture; P19 cells; SH-SY5Y cells; βIII-tubulin; Methylmercury; Okadaic acid; Acrylamide; MDMA; Piperazine-derived designer drugs.;

    Abstract : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. READ MORE

  6. 4. Alcohol and gene expression in nerve cells with emphasis on transcription factor AP-1

    Author : Ulrik Fried; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nerve cells; SH-SY5Y; muscarinic receptors; MAPKs; PKC; gene expression; jun; Activating Protein-1; Alcohol; ethanol; CRABP-I; Clinical chemistry; Klinisk kemi;

    Abstract : Alcohol induces profound effects on the function of the nerve cells in the nervous system. Alterations in gene expression is an important way by which these effects could be induced and sustained. Activating Protein-1 (AP-1) is a dimeric transcription factor constituted of proteins from the fos and jun immediate-early gene families. READ MORE

  7. 5. Effects of ethanol on muscarinic acetylcholine receptors in nerve cells

    Author : Murielle Hellsten Caron; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; nerve cell; SH-SY5Y; NOS; PKC; PLC; Ethanol; mAChR;

    Abstract : This thesis focused on the mechanisms involved in the effects of long-term ethanol treatment on mAChRs and their coupled-signal transduction pathway in human neuroblastoma SH-SY5Y cells. All 5 subtypes of mAChRs were expressed in these cells. READ MORE