Search for dissertations about: "SHB"

Showing result 1 - 5 of 18 swedish dissertations containing the word SHB.

2. 1. Shb and Its Homologues: Signaling in T Lymphocytes and Fibroblasts

   Author : Cecilia Lindholm; Hamid Band; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Shb; T cell receptor; IL-2 receptor; PDGF receptor; cell signaling; adapter proteins; LAT; Vav; PLC-g1; SLP-76; JAK1; JAK3; Jurkat cells; T cells; NK cells; Apoptosis.; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Stimulation of the T cell receptor (TCR) induces tyrosine phosphorylation of numerous intracellular proteins, leading to activation of the interleukin-2 (IL-2) gene in T lymphocytes. Shb is a ubiquitously expressed adapter protein, with the ability to associate with the T cell receptor and several signaling proteins in T cells, including: the TCR ζ-chain, LAT, PLC-γ1, Vav, SLP-76 and Gads. READ MORE

4. 2. The Role of the SHB Adapter Protein in Cell Differentiation and Development

   Author : Vitezslav Kriz; Michael Welsh; Urban Lendahl; Uppsala universitet; []
   Keywords : Cell biology; SHB; transgene; ES cells; cavitation; knockout; mouse; vasculogenesis; hematopoiesis; endoderm; mesoderm; malformation; Cellbiologi;

   Abstract : The present study was conducted in order to assess a role of the SH2 domain-containing adapter protein SHB in development and cell differentiation.Embryonic stem (ES) cells overexpressing SHB and SHB with an inactive SH2 domain (R522K-SHB) were obtained. READ MORE

5. 3. The role of Shb in ES cell differentiation, angiogenesis and tumor growth

   Author : Nina Funa; Michael Welsh; Leif Jansson; Lars Holmgren; Uppsala universitet; []
   Keywords : Cell biology; Shb; tyrosine kinase signaling; ES; endoderm; mesoderm; apoptosis; microvasculature; tumor growth; Cellbiologi;

   Abstract : Shb is a ubiquitously expressed adaptor protein with the ability to bind several tyrosine kinase receptors and intracellular signaling proteins. Previous studies have implied a wide spectrum of Shb-mediated cellular responses, which motivated me to further investigate the role of Shb in differentiation and angiogenesis. READ MORE

6. 4. The Role of Shb in Angiogenesis, FGF and VEGF Signalling in Endothelial Cells

   Author : Kristina Holmqvist; Michael Welsh; Eva Degerman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Shb; Src; FAK; Angiogenesis; VEGFR-2; FGFR-1; Endothelial cells; Spreading; Stress fiber formation; siRNA; VEGF; FGF; Differentiation; Migration; Tube formation; RNAi; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Abstract : Angiogenesis is defined as the formation of new capillary blood vessels from pre-existing ones. This process involves several steps including: migration, proliferation and differentiation of endothelial cells into blood vessels. READ MORE

7. 5. Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation

   Author : Lingge Lu; Michael Welsh; Lars Holgren; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Shb; Cbl; FGF-2; NGF; PDGF; VEGF; VEGFR-2; differentiation; blood vessel formation; PC12 cells; endothelial cells; embryoid bodies; Rap1; CrkII; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Abstract : Formation of blood vessels occurs through two processes: vasculogenesis and angiogenesis, which are regulated by various growth factors such as vascular endothelial growth factor, fibroblast growth factor and platelet-derived growth factor. The present study was carried out in order to investigate the roles of the Shb and Cbl proteins in growth factor-mediated signal transduction and blood vessel formation. READ MORE