Search for dissertations about: "SI-NET"

Showing result 6 - 10 of 13 swedish dissertations containing the word SI-NET.

  2. 6. Targeted radiotherapy in metastatic neuroendocrine tumours: clinical and experimental studies

    Author : Anna-Karin Elf; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroendocrine tumour; peptide receptor radionuclide therapy; somatostatin receptor 2 expression; radiosensitization; radioembolization; diffusion weighted imaging;

    Abstract : ABSTRACT Neuroendocrine tumours (NET) often present at a metastatic stage, which diminishes the possibility for curative surgery. Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE targets somatostatin receptors, which are overexpressed on NET cells. PRRT results in symptom relief and often tumour control of NETs, but rarely cure. READ MORE

  4. 7. Small Intestinal Neuroendocrine Tumor Analyses : Somatostatin Analog Effects and MicroRNA Profiling

    Author : Su-Chen Li; Valeria Giandomenico; Kjell Öberg; Marco Volante; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Small intestinal neuroendocrine tumors; Somatostatin analogs; Laser-capture microdissection; Microarray profiling and microRNA profiling; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Small intestinal neuroendocrine tumors (SI-NETs) originate from serotonin-producing enterochromaffin (EC) cells in the intestinal mucosa. Somatostatin analogs (SSAs) are mainly used to control hormonal secretion and tumor growth. However, the molecular mechanisms leading to the control of SI-NETs are unknown. READ MORE

  5. 8. Small Intestinal Neuroendocrine Tumor : A Rare Malignancy with Favorable Outcome

    Author : Olov Norlén; Peter Stålberg; Per Hellman; Peyman Björklund; Anders Sundin; Peter Naredi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroendocrine tumor; peritoneal carcinomatosis; single nucleotide polymorphism array; liver metastases; radiofrequency ablation; liver surgery; positron emission tomography; somatostatin analogs; cholecystectomy; Kirurgi; Surgery;

    Abstract : Small intestinal neuroendocrine tumor (SI-NET) is the most common small bowel tumor in Europe and USA, with an annual incidence of around 0.3-1.3/100000 persons. READ MORE

  6. 9. Molecular aspects of tumor development and treatment for small intestinal neuroendocrine tumors

    Author : Omid Fotouhi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Small intestinal neuroendocrine tumors (SI-NETs) may cause symptoms due to excess secretion of hormones and peptides. The molecular mechanisms behind development of SINETs are not well understood. Copy number alterations, especially loss of chromosome 18q, have been reported and recently p27 mutations were implicated in SI-NET tumorigenesis. READ MORE

  7. 10. Profiling of Small Intestine Neuroendocrine Tumors

    Author : Ellinor Andersson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumor; somatic copy number alteration; expression profiling; APLP1; survival; targeted therapy;

    Abstract : Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized disease. For most patients the disease follows a progressive and fatal course. READ MORE