Search for dissertations about: "SNT"

Showing result 1 - 5 of 6 swedish dissertations containing the word SNT.

  2. 1. On traumatic lesion to the spinal cord and dorsal spinal roots : factors influencing axonal regrowth across the border between the central and peripheral nervous system in the rat and man

    Author : Tomas Lindholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Immunohistochemistry; in situ hybridization; rat; man; axotomy; regeneration; motoneuron; ; CNS; PNS; tenascin; macrophages; BBB; scar; neuregulin; ErbB3 4; semaphorin; neuropilin; VEGF; olfactory system; DRG; DRT; SNT; SNC.;

    Abstract : Nerve cells are depending on their environment. Glial cells, astrocytes and oligodendrocytes in the central nervous system (CNS) make up a totally different milieu and characteristics than the distinguishing qualities of the peripheral nervous system (PNS), where the nerve cells are surrounded by Schwann cells. READ MORE

  4. 2. Spinal motoneurons and molecules related to neurotrophic function after axon injury

    Author : Henrik Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : immunohistochemistry; in situ hybridization; spinal cord; motoneuron; axotomy; survival; regeneration; MHC 1; leukocyte; cell culture; mRNA expression;

    Abstract : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. READ MORE

  5. 3. Adhesion molecules and synapse remodeling during motoneuron regeneration

    Author : Johan Zelano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Spinal motoneurons integrate a vast synaptic input and are the final conveyors of motor commands to skeletal muscle. Motoneuron regeneration includes altered contacts between the motoneuron and several other cell types. READ MORE

  6. 4. On laminins and laminin receptors and their roles in regeneration and myelination of the peripheral nerve

    Author : Wilhelm Wallquist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Motoneuron; dorsal root ganglion neuron; integrin; laminin; Schwann cell; Sciatic nerve; regeneration; myelination; in situ hybridization; immunohistochemistry and electron microscopy.;

    Abstract : One important prerequisite for successful axon regeneration is that appropriate extracellular molecules are available for outgrowing axons and that receptors for such molecules are found in the regenerating neuron. Laminin associated integrin subunits alpha3, alpha6, alpha7 and beta1 mRNAs are here shown to be present in rat motoneurons, and in the case of integrin subunits alpha7 and gamma1, also immunohistochemical (IHC) labelling of the proteins was demonstrated. READ MORE

  7. 5. Elimination of synapses from injured motoneurons : a model for study of synaptic plasticity in the adult central nervous system

    Author : Alexander Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synapses are the contacts between nerve cells or between nerve and muscle cells. The integrity of these synapses is crucial for proper function. Several neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis and neurotrauma involve synaptic pathology. READ MORE