Search for dissertations about: "SOLiD siRNA"

Showing result 1 - 5 of 13 swedish dissertations containing the words SOLiD siRNA.

  2. 1. miRNA and Asymmetric siRNA : Small RNAs with Large Effects on Bone Metabolism

    Author : Navya Laxman; Andreas Kindmark; Sara Windahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; miRNA; cp-siRNA; RNAi; bone; Osteoblast; Sequencing; Differential expression; Wnt pathway; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNA interference (RNAi) is a post-transcriptional gene silencing process elicited by double-stranded RNA, such as micro-RNA (miRNA) and small interfering RNA (siRNA). They are 18-25 nucleotide long, small non-coding RNAs acting as critical regulators in eukaryotic genome expression. READ MORE

  4. 2. Making Sense of Antisense

    Author : Johan Reimegård; Gerhart Wagner; Hanah Margalit; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; sRNA; miRNA; RNA; target prediction; SOLiD siRNA; E.coli; D.discoideum; Biology; Biologi; Bioinformatics; Bioinformatik; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNA is a highly versatile molecule with functions that span from being a messenger in the transfer from DNA to protein, a catalytic molecule important for key processes in the cell to a regulator of gene expression. The post-genomic era and the use of new techniques to sequence RNAs have dramatically increased the number of regulatory RNAs during the last decade. READ MORE

  5. 3. Cell-penetrating peptides; chemical modification, mechanism of uptake and formulation development

    Author : Kariem Ezzat; Ülo Langel; Steven Dowdy; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell penetrating peptides; gene therapy; scavenger receptors; pharmaceutical formulation; solid dispersion; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Gene therapy holds the promise of revolutionizing the way we treat diseases. By using recombinant DNA and oligonucleotides (ONs), gene functions can be restored, altered or silenced according to the therapeutic need. READ MORE

  6. 4. The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors

    Author : Kristofer Ahlqvist; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The tumor suppressor CYLD and the proto-oncogene BCL-3 are known to be deregulated in various cancer types. The molecular background of how these genes participate in carcinogenesis is not fully understood. READ MORE

  7. 5. Optimization of the formulation and design of oligonucleotide-based pharmaceuticals for the purpose of gene therapy

    Author : Eman M Zaghloul; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oligonucleotides (ONs) are short sequences of nucleic acids which may be used in a therapeutic context to modulate gene expression. According to their target, ONs can be classified into two main classes: antisense ONs which target mRNA and antigene ONs that target chromosomal DNA. READ MORE