Search for dissertations about: "SPE"

Showing result 11 - 15 of 66 swedish dissertations containing the word SPE.

2. 11. Development of 18F- and 68Ga-Labelled Tracers : Design Perspectives and the Search for Faster Synthesis

   Author : Elisabeth Blom; Bengt Långström; Oleksiy Itsenko; Irina Velikyan; Farhad Karimi; Frank Rösch; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; PET; nucleophilic 18F-fluorination; perfluoro; F-SPE; molecular design; 68Ga; chelators; DOTA; NOTA; microwave; halogen exchange; harmine; biotin; RGD; VEGF; CRP; Chemistry; Kemi; Organisk kemi; Organic Chemistry;

   Abstract : This thesis deals with the design of 18F- and 68Ga-labelled positron emission tomography (PET) tracers and the development of technologies that enable faster and simpler preparation with high specific radioactivity. Techniques like microwave heating and reducing the concentrations of the precursor were investigated with this perspective. READ MORE

4. 12. Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives

   Author : Ghazanfar Ali Khan; Jerker Fick; Klaus Kümmerer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

   Abstract : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. READ MORE

5. 13. Invasive group A streptococcal infection : host and pathogen interactions

   Author : Björn K G Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Group A streptococci; invasive infections; erysipelas; Streptococcal Toxic Shock Syndrome STSS ; epidemiology; M1 serotype streptococcal pyrogenic exotoxins Spe ; SpeA; toxin neutralization; opsonization;

   Abstract : Invasive group A streptococcal (GAS) infections were studied in 229 patients with a clinical diagnosis of erysipelas and 151 patients with GAS bacteremia, respectively. Beta-hemolytic streptococci were identified in about a third of the erysipelas patients, mostly group A, whereas group G streptococci were identified in about half as many episodes. READ MORE

6. 14. Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

   Author : Krister Karlsson; Lars Oreland; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Abstract : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. READ MORE

7. 15. High-throughput screening of solid-phase extraction materials using mass spectrometry

   Author : Kishore Jagadeesan; Avdelningen för Biomedicinsk teknik; []
   Keywords : mass spectromery; protein separation; sample preparation; Molecularly imprinted polymer; Data analysis; Data visualization; Miniaturisation; Proteomics;

   Abstract : In biomarker analysis, sample preparation plays a crucial step in order to extract, isolate and concentrate the analytes of interest. Among the various sample preparation techniques, solid phase extraction (SPE) is one of the most common and popular, due to the high enrichment factor, good recovery, low consumption of organic solvents and the possibility to automate (off- or on-line) the whole process. READ MORE