Search for dissertations about: "STABILITY STUDIES OF DRUGS"

Showing result 1 - 5 of 28 swedish dissertations containing the words STABILITY STUDIES OF DRUGS.

  1. 1. Stability of zopiclone in whole blood Studies from a forensic perspective

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Gunnel Nilsson; Linköpings universitet.; Linköpings universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Bio‐analytical results are influenced by in vivo factors like genetic, pharmacological and physiological conditions and in vitro factors like specimen composition, sample additives and storage conditions. The knowledge of stability of a drug and its major metabolites in biological matrices is very important in forensic cases for the interpretation of analytical results. READ MORE

  2. 2. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

    University dissertation from Lund University, dept. of Chemistry

    Author : Christopher Polonyi; Lunds universitet.; Lund University.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; platinum complexes; Anticancer drugs; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

    Abstract : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. READ MORE

  3. 3. Structural and functional studies of C4b-binding protein (C4BP)

    University dissertation from Lena Kask, Wallenberg Laboratory, floor 6, entrance 46, UMAS, S-205 02 Malmö

    Author : Lena Kask; Lunds universitet.; Lund University.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; phagocytosis; protein S; complement control protein CCP domains; factor H fH ; Complement; C4b-binding protein C4BP ; intracellular assembly; Clinical chemistry; Klinisk kemi;

    Abstract : The subject of this thesis is complement inhibitor C4b-binding protein (C4BP), on which we have performed both structural and functional studies. Complement is part of the innate immune defence and eliminates microbes, solubilises immune complexes and is involved in the clearance of apoptotic cells. READ MORE

  4. 4. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    University dissertation from Department of Chemistry, Lund University

    Author : Hanna Hedman; Lunds universitet.; Lund University.; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; platinum complexes; Anticancer drugs; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Abstract : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. READ MORE

  5. 5. Sterically stabilised liposomes and related lipid aggregates Fundamental studies on aggragate structure and stability

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Markus Johnsson; Uppsala universitet.; [2001]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; liposome; steric stabilisation; colloidal stability; cryo-TEM; drug delivery; Fysik; NATURAL SCIENCES Physics; NATURVETENSKAP Fysik; Physical Chemistry; fysikalisk kemi;

    Abstract : Various aspects of and approaches towards the steric stabilisation of liposomes have been investigated, mainly by use of fluorescence techniques and cryo-transmission electron microscopy (cryo-TEM). It is shown that PEG(2000)-lipids can be incorporated in the liposome membrane up to a critical concentration of 8-10 mol% without any observable structural perturbations. READ MORE