Search for dissertations about: "STABILITY STUDIES OF DRUGS"

Showing result 21 - 25 of 68 swedish dissertations containing the words STABILITY STUDIES OF DRUGS.

  2. 21. Oligomerization of human and bacterial frataxin : Structural and functional studies

    Author : Mostafa Abdalkhalik; Biokemi och Strukturbiologi; []
    Keywords : Frataxin; Friedreich’s ataxia; iron; reactive oxiden species; protein oligomerization; SAXS; EM; cross-linking; XAFS; nano- DSF;

    Abstract : Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by defeciency in frataxin, a highly conserved protein central to iron homeostasis in mirochondria. The function of frataxin is related to its capability to bind, store and deliver iron to different biochemical process such as iron-sulfur cluster assembly and heme biosynthesis. READ MORE

  4. 22. Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism

    Author : Anna Zimdahl; Malin Lindqvist Appell; Lars-Göran Mårtensson; Inger Johansson; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The thiopurines (6-mercaptopurine [6-MP], 6-thioguanine and azathioprine) are cytotoxic drugs used in the treatment of acute lymphoblastic leukemia (ALL), inflammatory bowel diseases, certain autoimmune diseases and after transplantation. The metabolism of thiopurines is complex with several enzymes involved in the conversion into active drug metabolites. READ MORE

  5. 23. Mechanisms of adaptation to the fitness cost of antibiotic resistance

    Author : Wilhelm Paulander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The dissemination and persistence of antibiotic resistance, is not only depending on the volume of drugs used but also on the resistance mechanisms effect of bacterial fitness (reproductive ability). Fitness is a multifactorial parameter that is comprised of the relative growth rate of the resistant pathogen in the host and in the environment, as well as the clearance and transmission rates compared to susceptible strains. READ MORE

  6. 24. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    Author : Lars Johannesen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. READ MORE

  7. 25. Evaluation of postmortem toxicological results

    Author : Carl Söderberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Postmortem diagnosis of fatal intoxications is complicated. Autopsy findings indicative of an intoxication related death are scarce and mostly unspecific. Instead, the diagnosis is more dependent on the circumstances surrounding death, and on the toxicological results. READ MORE