Search for dissertations about: "STAT3 inhibition"

Showing result 1 - 5 of 28 swedish dissertations containing the words STAT3 inhibition.

  2. 1. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

    Author : Ritha Gidlöf; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

    Abstract : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. READ MORE

  4. 2. Rule-Based Approaches for Large Biological Datasets Analysis : A Suite of Tools and Methods

    Author : Marcin Kruczyk; Jan Komorowski; Joaquin Dopazo; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Rough sets; peak finding; gliomas; Alzheimer disease; STAT3; machine learning; feature selection; next generation sequencing;

    Abstract : This thesis is about new and improved computational methods to analyze complex biological data produced by advanced biotechnologies. Such data is not only very large but it also is characterized by very high numbers of features. READ MORE

  5. 3. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Author : Martin H Johansson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Abstract : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. READ MORE

  6. 4. Regulation of Platelet-Derived Growth Factor Receptor Signaling and its Targeting in Cancer Therapy

    Author : Haisha Ma; Johan Lennartsson; Håkan Axelson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF; PDGFR; Ras; macropinocytosis; Fer; STAT3; HD-PTP; Cbl; ubiquitination; pericyte; vasculature; tumor; ASKA; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Abstract : Overactivity of platelet-derived growth factor receptor (PDGFR) is a frequent event in many types of solid tumors. Therefore, it is of great importance to uncover the mechanisms that regulate PDGF/PDGFR signalling, to develop efficient inhibitors targeting this pathway. READ MORE

  7. 5. Shedding light on the STAT3 small molecule inhibitor field

    Author : Sander Busker; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : STAT3 is one of the seven family members of the STAT transcription factor family. STAT3 has become a very attractive target for cancer therapy and other diseases. It has a prominent role in cancer development as well as progression. However, there are still no STAT3 inhibitors applied in the clinic. READ MORE