Search for dissertations about: "STAT5"

Showing result 1 - 5 of 29 swedish dissertations containing the word STAT5.

2. 1. Regulation of STAT5 activity by growth hormone

   Author : Tony J Pircher; Karolinska Institutet; Karolinska Institutet; []
   Keywords : growth hormone janus kinase; STAT5; MAP kinase; phosphatase;

   Abstract : The growth hormone (GH) receptor is a member of the cytokine receptor superfamily. This receptor family has certain common characteristics, among them the absence of a canonical tyrosine kinase consensus sequence and the association with the Janus family of cytosolic tyrosine kinases (JAK). The predominant JAK utilized by the GH receptor is JAK2. READ MORE

4. 2. STAT5 expression and regulation in mammary epithelial cells

   Author : Hanne Olsen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : STAT5; JAK2; PPAR-gamma; ER; MAPK; mammary epithelial cell differentiation;

   Abstract : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). READ MORE

5. 3. Estrogen receptor signalling in mammary epithelial cells

   Author : Malin Hedengran Faulds; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ER; STAT5; mammary epithelial cell differentiation; EGF; DAX-1;

   Abstract : The mammary gland is a complex tissue going through cycles of extensive proliferation and differentiation. Many hormones are involved in the regulation of development of the mammary gland, including estrogen, prolactin and epidermal growth factor (EGF). READ MORE

6. 4. Molecular mechanisms of alternative estrogen receptor signaling

   Author : Linda Björnström; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Estrogen is a key regulator of growth, differentiation and function in a broad range of target tissues, including the male and female reproductive tracts, mammary gland, bone, brain and the cardiovascular system. The biological effects of estrogen are mediated through estrogen receptor a (ERalpha) and estrogen receptor beta (ERbeta), which belong to a large superfamily of nuclear receptors that act as ligand-activated transcription factors. READ MORE

7. 5. Studies on growth hormone regulation of the CYP2C12 gene in rat liver

   Author : Hanna Helander; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Growth hormone (GH) is secreted from the pituitary gland in a sexually dimorphic manner in the rat. This leads to a sexual dimorphism in the expression of a number of hepatic GH-target genes including members of the cytochrome P450 (CYP) family. READ MORE