Search for dissertations about: "STIM1"

Showing result 1 - 5 of 6 swedish dissertations containing the word STIM1.

  2. 1. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    Author : Geng Tian; Erik Gylfe; Anders Tengholm; Patrick Gilon; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. READ MORE

  4. 2. Endoplasmic reticulum function in dendrites and dendritic spines of hippocampal neurons

    Author : Ai Na Ng; Sektion IV; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoplasmic reticulum; primary culture; dendritic spines; live cell imaging; STIM1; carbachol; store-operated calcium entry; 3; familial Alzheimer s disease; 5-dihyroxyphenyglycine;

    Abstract : In the hippocampus, dendritic spines are compartmentalized postsynaptic micro-domains in the excitatory synapse. Subsets of bigger and mushroom-shaped hippocampal dendritic spines contain tubules and cisterns of endoplasmic reticulum (ER) that are connected to the soma and dendrites of the neuron. READ MORE

  5. 3. Functional assays for the diagnosis of primary defects in lymphocyte cytotoxicity

    Author : Samuel C C Chiang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytotoxic lymphocytes encompass natural killer (NK) cells and cytotoxic T lymphocytes (CTL). These cells detect and kill virus-infected as well as malignant cells. Primary defects in lymphocyte cytotoxicity are associated with development of a hyperinflammatory syndrome termed hemophagocytic lymphohistiocytosis (HLH). READ MORE

  6. 4. Exploring the interactome of EF-hand proteins

    Author : Mikael Bauer; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; EF-hand; calcium; STIM; stromal interaction molecule; secretagogin; Calmodulin; calbindin D28k; protein-protein interactions; zinc; protein array;

    Abstract : EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. READ MORE

  7. 5. New insights in parathyroid hormone secretion : with focus on exocytosis and calcium signaling

    Author : Ming Lu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The parathyroid is distinguished from other endocrine systems since its primary stimuli inhibit hormone secretion. It is generally considered that extracellular Ca2+ binds to a membrane receptor (calcium sensing receptor, or CaSR), and via second messengers modulate parathyroid hormone (PTH) secretion. READ MORE