Search for dissertations about: "STRUCTURAL"

Showing result 1 - 5 of 5402 swedish dissertations containing the word STRUCTURAL.

  2. 1. Structural studies of proteins in apoptosis and lipid signaling

    Author : Maria Dolores Herman Moreno; Pär Nordlund; Markus Gruetter; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; proteins; crystal structure; apoptosis; cancer; CoFi-Blot; kinases; lipid signaling; Structural biology; Strukturbiologi; Structural Biology; strukturbiologi;

    Abstract : Signaling pathways control the fate of the cell. For example, they promote cell survival or commit the cell to death (apoptosis) in response to cell injury or developmental stimuli, decisions, which are vital for the proper development and functioning of metazoan. READ MORE

  4. 2. Structural studies of the surface adhesin SspB from Streptococcus gordonii

    Author : Nina Forsgren; Karina Persson; Inger Andersson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus gordonii; X-ray crystallography; surface adhesin; dental plaque; structural biology; Structural biology; Strukturbiologi; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Abstract : Surface proteins on microorganisms that build up the oral biofilm are key players in the formation of the biofilm. Antigen I/II proteins are surface adhesins found on virtually all oral streptococci and share a conserved multi-domain architecture. These adhesins bind surface components on other bacteria and on host cells. READ MORE

  5. 3. Fighting Tuberculosis – : Structural Studies of Three Mycobacterial Proteins

    Author : Alina Castell; Torsten Unge; Manfred Weiss; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mycobacterium tuberculosis; Rv0216; Rv0130; Mycobacterium smegmatis; branched chain aminotransferase; X-ray crystallography; fatty acid metabolism; Structural biology; Strukturbiologi;

    Abstract : This thesis presents the cloning, purification, crystallization, and structural studies of two unknown proteins from Mycobacterium tuberculosis, and of an aminotransferase from Mycobacterium smegmatis. Structural knowledge of these proteins is of highest interest for structure-based drug design, which is one of the approaches that can be used in order to fight tuberculosis (TB). READ MORE

  6. 4. Structural and functional properties of transthyretin

    Author : Anders Karlsson; A. Elisabeth Sauer-Eriksson; Salam Al-Karadaghi; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transthyretin; Amyloidosis; X-ray crystallography; Protein structure; Protein; Structural biology; Strukturbiologi;

    Abstract : The hereditary transthyretin (TTR) amyloidoses are rare, and in severe cases, fatal disorders caused by mutations in the TTR gene. The clinical picture is diverse, involving neuropathies and myopathies, and mainly depends on the causative mutation and the sites and rates of amyloid deposition. READ MORE

  7. 5. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

    Author : Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. READ MORE