Search for dissertations about: "Schwann cells"

Showing result 1 - 5 of 59 swedish dissertations containing the words Schwann cells.

  2. 1. Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans

    Author : Liza Grapensparr; Per-Ola Carlsson; Leif Jansson; Mia Phillipson; Aileen King; Uppsala universitet; []
    Keywords : Islets of Langerhans; beta cells; diabetes; transplantation; vascularization; Schwann cells; endothelial progenitor cells; neural crest stem cells; Medicinsk vetenskap; Medical Science;

    Abstract : Type 1 diabetes develops through the progressive destruction of the insulin-producing beta-cells. Regeneration or replacement of beta-cells is therefore needed to restore normal glucose homeostasis. Presently, normoglycemia can be achieved by the transplantation of whole pancreas or isolated islets of Langerhans. READ MORE

  4. 2. Schwann cells and mesenchymal stem cells as promoter of peripheral nerve regeneration

    Author : Maria Cristina Mantovani; Mikael Wiberg; Giorgio Terenghi; Susan Shawcross; Lev Novikov; Liudmila Novikova; John W Haycock; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve regeneration; Schwann cell; adult stem cell; myelin; senescence;

    Abstract : The transplantation of primary Schwann cells (SC) has been shown to improve nerve regeneration. However, to monitor the survival of transplanted cells within the host, a stable labelling method is required. READ MORE

  5. 3. Mesenchymal stem cells for repair of the peripheral and central nervous system

    Author : Maria Brohlin; Mikael Wiberg; Martin Birchall; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone marrow-derived stromal cells; Schwann cells; Peripheral nerve injury; Spinal cord injury; Neurotransplantation; anatomi; Human Anatomy; cell research; cellforskning;

    Abstract : Bone marrow-derived mesenchymal stem cells (MSC) have been shown to provide neuroprotection after transplantation into the injured nervous system. The present thesis investigates whether adult human and rat MSC differentiated along a Schwann cell lineage could increase their expression of neurotrophic factors and promote regeneration after transplantation into the injured peripheral nerve and spinal cord. READ MORE

  6. 4. Regulation of Injury Induced Schwann Cell Proliferation Schwann Cell Proliferation

    Author : Åsa Fex Svenningsen; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; estrogen; signal transduction; insulin like growth-factors; Schwann cell; peripheral; nerve regeneration; Djurfysiologi; Animal physiology; progesterone;

    Abstract : The purpose of this study was to investigate injury induced proliferation of Schwann cells with emphasis of the effects of the insulin-like growth factors (IGF-I and IGF-II) and the sex hormones progesterone and estrogen. Proliferation, measured as [3H] thymidine incorporation, was studied in cultured segments of the rat sciatic nerve or through the use of the thymidine analogue bromo- deoxy-uridine (BrdU) in combination with immunocytochemistry. READ MORE

  7. 5. Development of biosynthetic conduits for peripheral nerve repair

    Author : Aleksandra McGrath; Liudmila N Novikova; John Haycock; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biosynthetic conduit; Mesenchymal stem cells; Nerve graft; Nerve tissue engineering; Peripheral nerve injury; Schwann cells;

    Abstract : Peripheral nerve injuries are often associated with significant loss of nervous tissue leading to poor restoration of function following repair of injured nerves. Although the injury gap could be bridged by autologous nerve graft, the limited access to donor material and additional morbidity such as loss of sensation and scarring have prompted a search for biosynthetic nerve transplants. READ MORE