Search for dissertations about: "Sciatic nerve block"

Found 4 swedish dissertations containing the words Sciatic nerve block.

  2. 1. Long acting local anaesthetics - a study in rats

    Author : Henrik Dyhre; Anestesiologi och intensivvård; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; in vivo and effect kinetics; Comparison of in vitro; Neuro toxicity; Infraorbital nerve block; Sciatic nerve block; Lipid depot formulation;

    Abstract : Local anaesthetics provide excellent pain relief after central and peripheral nerve blocks. However, in many clinical situations there is an insufficient duration of action to allow effective treatment of long-term pain with single injection techniques. This problem became the focus of the present studies. READ MORE

  4. 2. In Vitro – In Vivo Correlation of Injectable Lipid Formulations

    Author : Lars Söderberg; Livsmedelsteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; EC 50; erythrocyte; human plasma; lipid injectable formulation; IVIVC; fatty acid; in vitro release; Peripheral nerve block; neurolytic; structure-activity;

    Abstract : In order to develop new pharmaceuticals, to optimize pharmacotherapy and secure patient safety, documentation of the properties of pharmaceutical formulations is a most important process. A significant practical problem associated with pre-clinical evaluation of lipophilic substances with pharmacological properties is their low aqueous solubility. READ MORE

  5. 3. Neural crest in development and repair

    Author : Jorge Benjamín Aquino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis is focused on several aspects of neural crest biology, largely related to two main issues: 1) understanding its mechanisms of migration and 2) analyzing the potential of neural crest stem cells or their derivatives for nervous system repair. If repair is the aim, knowledge of both timing and events leading to axonal degeneration is required in order to block it and/or increase regeneration outcome. READ MORE

  6. 4. Bilateral neurogenic mechanisms following acute unilateral inflammation

    Author : Indre Bileviciute-Ljungar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : bilateral changes; host defence reaction; contralateral treatment; dorsal root reflexes; cross-spinal reflexes; substance P; neurokinin A; calcitonin gene-related peptide; neuropeptide Y; nociception; inflammation; carrageenan; edema; hindpaw withdrawal latency; microdialysis; hot-plate test; Randall Selitto test;

    Abstract : The contribution of neurogenic mechanisms to inflammation has been extensively studied during the last decade, but provides no clear understanding of the bilateral changes commonly seen following unilateral stimulation. This work demonstrates that bilateral neurogenic mechanisms are a part of general host defence reactions following acute unilateral challenge, for the first time revealing that local anaesthetics applied contralaterally, might be used for therapeutic purposes in relieving pain and inflammation. READ MORE