Search for dissertations about: "Secondary ions mass spectrometry"

Showing result 1 - 5 of 14 swedish dissertations containing the words Secondary ions mass spectrometry.

  2. 1. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry

    Author : Christopher Adams; Roman Zubarev; Göran Possnert; Carlito Lebrilla; Uppsala universitet; []
    Keywords : Engineering physics; Protein Structure; Mass Spectrometry; Electron Capture Dissociation; Tandem Mass Spectrometry; Teknisk fysik;

    Abstract : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). READ MORE

  4. 2. High Rate Electron Capture Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    Author : Youri Tsybin; Per Håkansson; Ron M.A. Heeren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; mass spectrometry; Fourier transform ion cyclotron resonance; peptides and proteins; ion-electron interaction; electron capture dissociation; infrared multiphoton dissociation; liquid chromatography; capillary electrophoresis; Fysik; Physics; Fysik;

    Abstract : Advances in science and technology during the past decade have greatly enhanced the level of the structural investigation of macromolecules – peptides and proteins. Biological mass spectrometry has become one of the most precise and sensitive techniques in peptide and protein analysis. READ MORE

  5. 3. Label free analysis and spatial distribution of molecular lipids in brain tissue and cells using mass spectrometry imaging

    Author : Amir Saeid Mohammadi; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry Imaging; Secondary Ion Mass Spectrometry Imaging; Matrix Assisted Laser desorption Ionization; Lipids; Brain tissue;

    Abstract : Lipids are important inherent components in brain and cell membranes, which play significant biological roles in cell function. Identification and localization of specific biomolecules such as peptides and lipids within cellular membranes is currently a major challenge in metabolomics and biological studies. READ MORE

  6. 4. Application of imaging TOF-SIMS in cell and tissue research

    Author : Katrin Richter; Göteborgs universitet; []
    Keywords : TOF-SIMS; imaging mass spectrometry; cryopreparation; ions; lipids; galactosylceramide; sulfatide; fatty acids;

    Abstract : This thesis is aimed at extending the use of TOF-SIMS (time of flight secondary ion mass spectrometry) as an analytical tool in cell and tissue research. TOF-SIMS is a relatively new method that allows analysis of the chemical composition of sample surfaces. READ MORE

  7. 5. Mass spectrometry of biopolymers based on ion-induced desorption

    Author : Roman Alexandrovich Zubarev; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Strålningsvetenskap; Radiation biology; Strålningsbiologi; Ion Physics; jonfysik;

    Abstract : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. READ MORE