Search for dissertations about: "Sequence Deletion"

Showing result 1 - 5 of 102 swedish dissertations containing the words Sequence Deletion.

  2. 1. Antibody Evolution and Repertoire Development

    Author : Johan Lantto; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; virus neutralization; trinucleotide repeat; insertion; immunoglobulin variable genes; human cytomegalovirus; glycoprotein B; deletion; antibody; antibody repertoire;

    Abstract : Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. READ MORE

  4. 2. Bioinformatic Analysis of Mutation and Selection in the Vertebrate Non-coding Genome

    Author : Mikael Brandström; Hans Ellegren; Diethard Tautz; Uppsala universitet; []
    Keywords : Biology; non-coding genome; selection; mutation; chicken; human; indel; microsatellite; sequence alignment; comparative genomics; bioinformatics; vertebrate; Biologi;

    Abstract : The majority of the vertebrate genome sequence is not coding for proteins. In recent years, the evolution of this noncoding fraction of the genome has gained interest. These studies have been greatly facilitated by the availability of full genome sequences. READ MORE

  5. 3. Mine the Gaps : Evolution of Eukaryotic Protein Indels and their Application for Testing Deep Phylogeny

    Author : Pravech Ajawatanawong; Sandra Baldauf; James McInerney; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; indel; insertion deletion; protein evolution; bioinformatics; non-bilateria; eukaryotes; phylogeny; Biology with specialization in Systematics; Biologi med inriktning mot systematik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : Insertions/deletions (indels) are potentially powerful evolutionary markers, but little is known about their evolution and few tools exist to effectively study them. To address this, I developed SeqFIRE, a tool for automated identification and extraction of indels from protein multiple sequence alignments. READ MORE

  6. 4. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

    Author : Xinrong Hu; Björn Hagmar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. READ MORE

  7. 5. Random graph models and their applications

    Author : Thomas Vallier; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; contact process; phase transition; classical random graphs; degree sequence; preferential attachment; percolation; random graphs;

    Abstract : This thesis explores different models of random graphs. The first part treats a change from the preferential attachment model where the network incorporates new vertices and attach them preferentially to the previous vertices with a large number of connections. READ MORE