Search for dissertations about: "Siamak Haghdoost"

Showing result 1 - 5 of 13 swedish dissertations containing the words Siamak Haghdoost.

  2. 1. Biomarkers of oxidative stress and their application for assessment of individual radiosensitivity

    Author : Siamak Haghdoost; Mats Harms-Ringdahl; Steffen Loft; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oxidative stress; 8-oxo-dG; 8-oh-dG; Radiosensitivity; Toxicology; Toxikologi;

    Abstract : Radiotherapy is one of the most common therapeutic methods for treatment of many types of cancer. Despite many decades of development and experience there is much to improve, both in efficacy of treatment and to decrease the incidences of adverse healthy tissue reactions. READ MORE

  4. 2. In vitro and in vivo aspects of intrinsic radiosensitivity

    Author : Karl Brehwens; Andrzej Wojcik; Siamak Haghdoost; Wolfgang Dörr; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; changing dose rates; cytogenetics; hypothermia; X-rays; radiotherapy; osteoradionecrosis; biomarkers; oxidative stress; individual radiosensitivity; molekylär biovetenskap; Molecular Biosciences;

    Abstract : This thesis focuses on how physical and biological factors influence the outcome of exposures to γ/X-rays. That the dose rate changes during real life exposure scenarios is well-known, but radiobiological data from exposures performed at increasing or decreasing dose rates is lacking. READ MORE

  5. 3. Factors modifying cellular response to ionizing radiation

    Author : Lei Cheng; Andrzej Wojcik; Siamak Haghdoost; Lovisa Lundholm; Penelope A. Jeggo; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Radiation biology; DNA damage; gene expression; alpha particles; X-rays; mixed beams; gamma rays; hypothermia; dose rate.; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Many physical factors influence the biological effect of exposure to ionizing radiation, including radiation quality, dose rate and temperature. This thesis focuses on how these factors influence the outcome of exposure and the mechanisms behind the cellular response. READ MORE

  6. 4. The role of MTH1 in ultraviolet radiation-induced mutagenesis

    Author : Asal Fotouhi; Siamak Haghdoost; Harry Vrieling; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ultraviolet radiation; MTH1; reactive oxygen species; 8-oxo-dGTP; 2-OH-dATP; micronucleus; molekylärgenetik; Molecular Genetics;

    Abstract : Ultraviolet radiation (UVR) is known to be highly mutagenic. What types of DNA lesions that are induced by different UVR wavelengths are still a matter of debate. UVR induces mutagenesis mostly by the formation of photoproducts and the induction of reactive oxygen species (ROS). READ MORE

  7. 5. Oxidized nucleotides as a predictor of radiation sensitivity

    Author : Ali Pour Khavari; Siamak Haghdoost; Marie Öhman; Anders Nilsson; Bo Stenerlöw; Neus Visa; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 8-oxo-dG; Radiation; Sensitivity; Oxidized; Nucleotides; ROS; NOS; molekylär biovetenskap; Molecular Bioscience;

    Abstract : The direct and indirect effects of IR can lead to DNA damage and activation of DNA repair. The indirect effects of ionizing radiation mediated by reactive oxygen species (ROS) which produced through radiolysis of water and if not taken care of by the antioxidant system, can also give rise to oxidative stress. READ MORE