Search for dissertations about: "Sibylle Neuhoff"

Found 1 swedish dissertation containing the words Sibylle Neuhoff.

  1. 1. Refined in vitro Models for Prediction of Intestinal Drug Transport : Role of pH and Extracellular Additives in the Caco-2 Cell Model

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sibylle Neuhoff; Uppsala universitet.; [2005]
    Keywords : Medical and Health Sciences Basic Medicine Pharmaceutical Sciences; Medicin och hälsovetenskap Medicinska grundvetenskaper Farmaceutisk vetenskap; Pharmacy; Caco-2 cells; membrane permeability; drug permeation; drug efflux ratios; drug uptake ratios; Cremophor EL; bovine serum albumin; pH-dependent permeability; drug transport; FARMACI; PHARMACY; FARMACI;

    Abstract : Drug transport across the intestinal epithelium is roughly predicted from permeability values obtained from Caco-2 cell monolayers. This thesis examines the important role of pH and extracellular additives for increasing the reliability and predictivity of the in vitro screening system, Caco-2. READ MORE