Search for dissertations about: "Simone Grethe"

Found 1 swedish dissertation containing the words Simone Grethe.

2. 1. p38 MAPK Signalling in Endothelial Apoptosis

   Author : Simone Grethe; Malmö Experimentell patologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

   Abstract : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. READ MORE