Search for dissertations about: "Smad2 3"
Showing result 1 - 5 of 16 swedish dissertations containing the words Smad2 3.
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1. Mechanisms and treatment options of chronic graft dysfunction : Experimental and clinical studies
Abstract : Chronic graft dysfunction (CGD) is an important post-transplant complication. CGD can be considered as an impaired repair process, which ultimately leads to the loss of graft function.To study non-immunological factors contributing to the development of CGD in kidney grafts we used in vitro and in vivo models, and clinical studies. READ MORE
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2. Acute pancreatitis, from local defense to remote organ injury
Abstract : Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung injury (ALI). READ MORE
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3. Oxysterol receptors LXRs and coregulators in cholesterol metabolism and inflammatory transrepression pathways
Abstract : The LXRs are important sensors and regulators of cholesterol homeostasis in several metabolic tissues including liver, intestine and macrophages. They regulate target genes involved in cholesterol-, lipid- and carbohydrat metabolism. Recently, the LXRs have emerged as important regulators of the innate and adaptive immune system and inflammation. READ MORE
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4. Gene regulation by different proteins of TGFβ superfamily
Abstract : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. READ MORE
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5. Transforming growth factor-ß. Signal regulation in health and disease
Abstract : TGF-b superfamily members have been shown to play a pivotal role in multicellular organisms. Knowledge about signal transduction pathways is important in order to understand and cure diseases like cancer where TGF-b´s growth inhibitory signal often are disenabled via mutated or absent signalling components. READ MORE
