Search for dissertations about: "Small RNA"

Showing result 16 - 20 of 315 swedish dissertations containing the words Small RNA.

  2. 16. Novel inhibitors of Chlamydia trachomatis virulence

    Author : Carlos Nunez-Otero; Åsa Gylfe; Sven Bergström; Fredrik Almqvist; Jörgen Johansson; Patrik Bavoil; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chlamydia trachomatis; 2-pyridone; small molecules; KSK213; Structure-Activity Relationships SAR ; antibiotic resistance; target identification; transcription; RNA; progeny; infectivity;

    Abstract : Chlamydia trachomatis is an obligate intracellular bacterium that infects over 100 million people globally every year. Chlamydia infections can be persistent, cause infertility and blindness, adding an economical burden in the healthcare systems. READ MORE

  4. 17. Lead(II) as a Tool for Probing RNA Structure in vivo

    Author : Magnus Lindell; Gerhart Wagner; Roland Hartmann; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; lead II cleavage; RNA structure; in vivo probing; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Chemical modification and limited enzymatic hydrolysis are powerful methods to obtain detailed information on the structure and dynamics of RNAs in solution. In the work presented here I have taken advantage of the properties of the divalent metal ion lead(II) to establish it as a new probe for investigating the structure of RNA in vivo. READ MORE

  5. 18. Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

    Author : Christopher Polonyi; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; duplex melting; thermodynamic stability; kinetics; non-coding RNA; miRNA; siRNA; wobble base pair; loop; BRCA1; mimic; luciferase assay;

    Abstract : Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. READ MORE

  6. 19. Exploring small airways using breath analyses

    Author : Emilia Viklund; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exhaled particles; small airways; alveolar nitric oxide; SARS-CoV-2; birch pollen; smoking; lining fluid;

    Abstract : Background: Airway irritants such as allergens, tobacco smoke and viruses may cause damage in the small airways, usually undetected with routine diagnostic methods. Analyses of endogenously produced nitric oxide (NO) and endogenously produced small droplets (i.e. READ MORE

  7. 20. Nucleic Acids as Drugs and Drug Targets With Focus on Anticancer Active Platinum Complexes and Small Interfering RNAs

    Author : Hanna Hedman; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Anticancer drugs; platinum complexes; cisplatin; oxaliplatin; nucleic acid; RNA; DNA; siRNA; thermodynamic stability; mass spectrometry; MALDI-MS; chemical probing; luciferase assay;

    Abstract : To ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. READ MORE