Search for dissertations about: "Solid-phase synthesis"
Showing result 1 - 5 of 82 swedish dissertations containing the words Solid-phase synthesis.
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1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy
Abstract : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. READ MORE
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2. Methodological studies in solid phase synthesis : Linkers and applications of multi-component condensations
Abstract : Solid phase synthesis has become an increasingly important tool in the synthesis of oligopolymers and small organic molecules. This thesis covers three important areas in the solid phase synthesis technique: linker strategies, reduction methods and novel routes to complex heterocycles. READ MORE
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3. Glycoconjugates : Solid-phase synthesis and biological applications
Abstract : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. READ MORE
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4. Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides
Abstract : Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. READ MORE
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5. Iron Carbonyl Mediated Parallel Synthesis
Abstract : This thesis describes the examination and development of cationic iron carbonyl complexes for use in parallel synthesis both in solution phase and on solid phase. A solution phase methodology for carbon-carbon and carbon-heteroatom formation, utilizing polymer bound reagents and scavengers and amenable for automation has been successfully developed. READ MORE