Search for dissertations about: "Spheroid"

Showing result 1 - 5 of 39 swedish dissertations containing the word Spheroid.

  2. 1. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

    Author : Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
    Keywords : Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

    Abstract : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. READ MORE

  4. 2. Proteomics informed investigation of human hepatocytes and liver tissue

    Author : Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. READ MORE

  5. 3. Ultrasonic Fluid and Cell Manipulation

    Author : Mathias Ohlin; Martin Viklund; Hans Hertz; Peter Glynne-Jones; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 3D cell culture; Acoustic streaming; Acoustofluidics; Cell manipulation; High-resolution imaging; Multi-well; Microplate; Natural killer cell; Piezo; Radiation force; Solid tumor; Solubilization; Spheroid; Standing wave; Temperature control; Transducer; Trapping; Ultrasonic; Fysik; Physics; Biological Physics; Biologisk fysik;

    Abstract : During the last decade, ultrasonic manipulation has matured into an important tool with a wide range of applications, from fundamental cell biological research to clinical and industrial implementations. The contactless nature of ultrasound makes it possible to manipulate living cells in a gentle way, e.g. READ MORE

  6. 4. Acoustic manipulation for cell and spheroid cellomics

    Author : Karl Olofsson; Martin Viklund; Maria Tenje; KTH; []
    Keywords : Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

    Abstract : Ultrasonic standing wave (USW) particle manipulation has during the last two decades matured into a valuable tool to combine with microfluidics. Acoustophoresis, migration through sound, is the result of the acoustic radiation force acting on particles suspended in an acoustic field. READ MORE

  7. 5. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

    Author : Azita Monazzam; Mats Bergström; Carl Blomqvist; Jörgen Carlsson; Raymond Josephsson; Eric O Aboagye; Uppsala universitet; []
    Keywords : Oncology; Positron Emission Tomography; Multicellular Tumour Spheroid; Translational Research; Onkologi;

    Abstract : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. READ MORE