Search for dissertations about: "Sterol"

Showing result 11 - 15 of 52 swedish dissertations containing the word Sterol.

  2. 11. Requirement for mevalonate-derived lipids in cell proliferation : a study of the role of polyisoprenoid alcohols

    Author : Johan Wejde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mevalonic acid constitutes a key intermediate in the biosynthesis of a number of isoprenoid products. These metabolites include cholesterol and sterol-derived molecules, but also a large number of non-sterol isoprene derivatives. READ MORE

  4. 12. Studies on the regulatory roles of cholesterol and bile acids

    Author : Charlotte Murphy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cholesterol; cholic acid; bile acids; cholesterol homeostasis; squalene epoxidase; mevalonate kinase; cob I alamin adenotransferase; SREBP; NF-Y;

    Abstract : Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol can be harmful leading to diseases such as atherosclerosis and gallstones. Once formed the ring structure of cholesterol cannot be catabolised by the body and must therefore be converted to other compounds for excretion. READ MORE

  5. 13. Dietary intake of naturally occurring plant sterols in relation to serum cholesterol and myocardial infarction - Epidemiological studies from Sweden and the UK

    Author : Sofia Klingberg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; plant sterols; dietary intake; food sources; serum cholesterol; CVD; myocardial infarction; nutrition; epidemiology;

    Abstract : Cardiovascular diseases (CVDs) are the leading cause of death in the world. High serum level of cholesterol is one of the major risk factors for CVD development. Serum levels of cholesterol can be modified by diet. READ MORE

  6. 14. Cell death in atherosclerosis

    Author : Milita Crisby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; carotid artery stenosis; ischemic stroke; apoptosis; necrosis; lipid peroxidation; plaque stability; pravastatin; inflammation; 27-[alpha]-hydroxylase;

    Abstract : Rupture of atherosclerotic lesions is recognized as the major cause of acute cerebrovascular and coronary syndromes. The characteristics of the typical vulnerable plaque include increased inflammatory cells at the shoulder region, a large lipid core, a thin fibrous cap with few collagen fibers and smooth muscle cells. READ MORE

  7. 15. Use of primary human hepatocytes for the elucidation of bile acid synthesis

    Author : Ewa C S Ellis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the present investigation we cultured primary human hepatocytes on matrigel under serum-free conditions and studied bile acid formation. The following observations were made: · The major steroid products excreted from primary human hepatocytes into the culture medium were cholic acid, CA (70%) and chenodeoxycholic acid, CDCA (25%) conjugated with glycine or taurine. READ MORE