Search for dissertations about: "Stromelysin"
Found 5 swedish dissertations containing the word Stromelysin.
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1. Legg-Calvé-Perthes´ disease. Synovitis, cartilage, remodeling
Abstract : This thesis evaluates and correlates the findings in a series of children with Legg-Calvé-Perthes´ Disease at the Departments of Orthopedics, University Hospitals in Lund, Sweden and Odense, Denmark during 1984-1993. It focuses on the importance of synovitis and its effect on the cartilage, on the shape of the femoral head in the early phases of LCPD and on femoral head remodeling after proximal femoral varus derotation osteotomy. READ MORE
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2. Positive and negative angiogenic factors in patients with malignant disease
Abstract : In this thesis, the levels of positive and negative angiogenic factors were studied in tissue, serum and urine from patients with malignant disease. The angiogenic factors VEGF (vascular endothelial growth factor) and bFGF (basic fibroblast growth factor) were studied in breast carcinomas. READ MORE
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3. Studies on basal cell carcinoma with emphasis on the role of the human homologue of the Drosophila patched gene
Abstract : Basal cell cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. Ultraviolet radiation (WR) is presumed to be the predominant environmental factor. READ MORE
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4. Injury-induced activation of vascular smooth muscle cells. Role of specific gene expression and intracellular signalling pathways
Abstract : Migration and proliferation of smooth muscle cells (SMC) are important events in the development of atherosclerosis and restenosis following angioplastic surgery. It is important to gain further knowledge about the mechanisms regulating SMC form and function in order to understand the underlying disease process. READ MORE
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5. Theoretical Modeling of Enzyme Catalysis with Focus on Radical Chemistry
Abstract : Hybrid density functional theory (DFT) B3LYP method is applied to study the four diverse enzyme systems: zinc-containing peptidases (thermolysin and stromelysin), methyl-coenzyme M reductase, ribonucleotide reductases (classes I and III), and superoxide dismutases (Cu,Zn- and Ni-dependent enzymes). Powerfull tools of modern quantum chemistry are used to address the questions of biological pathways at their molecular level, proposing a novel mechanism for methane production by methyl-coenzyme M reductase and providing additional insights into hydrolysis by zinc peptidases, substrate conversion by ribonucleotide reductases, and biological superoxide dismutation. READ MORE
