Search for dissertations about: "Structural Elucidation"

Showing result 11 - 15 of 57 swedish dissertations containing the words Structural Elucidation.

  2. 11. Phytoglobins: Elucidation of Structural, Functional and Practical Features of Non-Symbiotic Plant Hemoglobins

    Author : Simon Christensen; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hemoglobin; Fytoglobin; Hexakoordination; Karaktärisering; Protein design; Rekombinant protein production; Kromatografi; kristallografi; Dimerisering; Protein Dynamik;

    Abstract : Phytoglobins (Pgb) (plant hemoglobins) are heme-containing proteins and less well known in comparison to the mammalian counterparts hemoglobin (Hb) andmyoglobin (Mb). They share the same secondary structure as other globin-related proteins, six to eight α-helices comprising the myoglobin-fold (Mb-fold) with one prosthetic heme moiety per subunit. READ MORE

  4. 12. Structural / functional studies on human alkaline phosphatases

    Author : Alexey Kozlenkov; Jose-Luis Millan; Hans Jörnvall; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; mutagenesis; enzyme kinetics; computer modeling; crystallography; natural substrates; uncompetitive inhibition; isozymes; gene families; Biomedicin; Microbiology; Mikrobiologi; medicinsk genetik; Medical Genetics;

    Abstract : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. READ MORE

  5. 13. Terpenoid Plant Metabolites - Structural Characterization and Biological Importance

    Author : Eliana Maldonado; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Terpenoid Sesquiterpene lactones Breast-cancer cell lines Cytotoxicity Antileishmanicial Structural characterization;

    Abstract : In response to the challenges of their local environments, organisms produce of a large number of chemical diverse compounds with complex stereochemistry and reactive functional groups. These characteristics enable them to interact and bind specifically to biological target molecules and exert various biological activities, and have assured that Natural products continues to be an important source of bioactive compounds, which, for example, facilitate the search for new lead structures that can be developed into new pharmaceuticals. READ MORE

  6. 14. Structural studies on lipopolysaccharides from haemophilus species

    Author : Brigitte Twelkmeyer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Carbohydrates are indispensable mediators for a variety of cellular interactions. In biological systems carbohydrates are usually linked to a carrier as e.g. proteins or lipids. READ MORE

  7. 15. NMR as a tool in drug research : Structure elucidation of peptidomimetics and pilicide-chaperone complexes

    Author : Mattias Hedenström; Jan Jan Kihlberg; Ingmar Sethson; Michael P. Williamson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; NMR; structure calculations; peptidomimetics; desmopressin; Leu-enkephalin; chemical shift mapping; pilicides; chaperones; urinary tract infections.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in the pharmaceutical industry. This thesis describes applications of NMR spectroscopy in biomedicinal research for structure elucidation of biologically active peptides and peptidomimetics as well as in studies of ligand-protein interactions. READ MORE