Search for dissertations about: "T. Wu"

Showing result 1 - 5 of 8 swedish dissertations containing the words T. Wu.

  2. 1. The role of adenosine and its receptor subtypes in nociception and neuropathic pain

    Author : Weiping Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; adenosine receptors; antinociception; caffeine; knock-out mouse; neuropathy; morphine; R-PIA;

    Abstract : As neurotransmitter/modulator, adenosine plays an important role in nociceptive processing. Adenosine receptors are G-protein coupled and four receptor subtypes, A1, A2A, A2B and A3 have been identified. It is well established that adenosine and its receptor agonists produce primarily antinociceptive effect in animals and humans. READ MORE

  4. 2. Regulation of insulin secretion in diabetes: Molecular mechanism and applications

    Author : Rui Wu; Diabetes - öpatofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin production secretion; CaV channels; DEGs; aging; magnetic field;

    Abstract : Diabetes is a highly ageing-related disease manifesting with a deteriorated capacity of insulin secretion and uncontrolled blood glucose-raising, hyperglycemia. In this thesis, we aim to explore the underlying roles of CaV channels and aging-associated genetic changes in the development of Type 2 diabetes (T2D). READ MORE

  5. 3. Immune reactions against oxidatively modified low density lipoproteins in patients with atherosclrosis and healthy individuals

    Author : Ruihua Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Immune-inflammatory mechanisms are involved in the development of atherosclerosis, and immune reactions against oxidatively modified LDL have received special interest. In the present study, we have investigated the effect of oxLDL on the stimulation of peripheral blood mononuclear cells (PBMC) to increased DNA-synthesis and cytotoxicity and the nature and the prevalence of antibodies against oxLDL in healthy individuals and in patients with atherosclerosis. READ MORE

  6. 4. Experimental studies on xenograft rejection

    Author : Guosheng Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The use of animal organs and tissues may provide a solution to the severe and worsening shortage of human grafts. The aims of the present experimental studies were to provide a better understanding of the rejection mechanisms and give new clues for prevention of xenorejection, thereby hopefully contributing to the development of clinical xenotransplantation. READ MORE

  7. 5. Functional genomics at the interface of protein expression and biophysical analysis

    Author : Xiaoqiu Wu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Protein characterization is central to any functional genomics effort, hence protein expression and purification play fundamental roles in these initiatives. In this study strategies for protein expression in E. coli were analysed, and several parameters were investigated respect to high-level expression of functional proteins. READ MORE