Search for dissertations about: "TACE"

Showing result 1 - 5 of 12 swedish dissertations containing the word TACE.

  2. 1. α-Secretase processing of the Alzheimer amyloid-β precursor protein and its homolog APLP2

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Olav Andersen; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP2; ADAM10; TACE; Alzheimer s Disease; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : The amyloid-β precursor protein (APP) has been widely studied due to its role in Alzheimer´s disease (AD). When APP is sequentially cleaved by β- and γ-secretase, amyloid-β (Aβ) is formed. Aβ is prone to aggregate and is toxic to neurons. READ MORE

  4. 2. TRAF6, a key regulator of TGFβ-induced oncogenesis in prostate cancer

    Author : Reshma Sundar; Marene Landström; Carl-Henrik Heldin; Petra Knaus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TβRI; TGFβ; TACE; TRAF6; PS1; PKCζ; TβRI-ICD; NICD; Smad; non-Smad; prostate cancer; Snail1; MMP; p300; p21; PAI1; ubiquitination; cleavage; ICD; invasion; HES1; signaling; patologi; Pathology;

    Abstract : Prostate cancer is the most common cancer in men, with the incidence rapidly increasing in Europe over the past two decades. Reliable biomarkers for prostate cancer are currently unavailable. Thus, there is an urgent need for improved biomarkers to diagnose prostate cancer at an early stage and to determine the best treatment options. READ MORE

  5. 3. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells

    Author : Shyam Kumar Gudey; Marene Landström; Urban Lendahl; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-Jun; invasion; non-Smad; Notch; NICD; oncogenesis; presenilin1; PKCζ; prostate cancer; p21; p38; p300; Snail1; TGFβ; TβRI; TACE; TRAF6; ubiquitination; TGFbeta signal transduction; Pathology; patologi;

    Abstract : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. READ MORE

  6. 4. Processing of the APP family by the α-secretases ADAM10 and TACE

    Author : Kristin Jacobsen; Kerstin Iverfeldt; Lars Nilsson; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. READ MORE

  7. 5. Transarterial chemoembolization in primary liver and kidney malignancies

    Author : Amar Karalli; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and the most current treatment for unresectable hepatocellular carcinoma is transarterial chemoembolization using drug-eluting beads (DEB-TACE). The concept of TACE might also technically be applicable to other types of hypervascular cancers such as renal cell carcinoma (RCC). READ MORE