Search for dissertations about: "TCR activation."

Showing result 1 - 5 of 76 swedish dissertations containing the words TCR activation..

  2. 1. Regulation of activation of NF-κB by Calmodulin in T-lymphocytes

    Author : Sreenivasa Rao Oruganti; Thomas Grundström; Eva Sverinson; Umeå universitet; []
    Keywords : Calcium; Calmodulin; CaMKII; TCR; Bcl10; NF-κB;

    Abstract : Nuclear factor kappa B (NF-kB) is a widely expressed family of transcription factors that are involved in a diverse number of processes. These include inflammation or differentiation, survival or apoptosis, and proliferation or cell cycle arrest. READ MORE

  4. 2. Staphylococcal enterotoxin H - structure and function of a superantigen

    Author : Helen Pettersson; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; TCR; staphylococcal enterotoxin H; MHC class II; superantigen; transplantation; Immunologi; serologi; serology;

    Abstract : The aim of this thesis was to characterise the biological functions of the superantigen staphylococcal enterotoxin H (SEH). Superantigens are highly immunostimulatory proteins, which crosslink T cells and antigen presenting cells (APCs). READ MORE

  5. 3. Interplay between superantigens and immunoreceptors

    Author : Karin Lindkvist; Medicinsk strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; serology; Immunology; TCR; MHC class II; X-ray crystallography; superantigen; staphylococcal enterotoxin; Biofysik; transplantation; Immunologi; serologi; Biophysics;

    Abstract : This thesis deals with the interactions between superantigens and their receptors. Superantigens are proteins that are secreted by various bacteria, such as Staphylococcus aureus and Streptococcus pyogenes. Superantigens are able to cross-link T cells and antigen presenting cells by binding to the T cell receptor (TCR) and MHC class II. READ MORE

  6. 4. Tumor-targeted superantigens for experimental immunotherapy of human leukemia/lymphoma

    Author : Cecilia Weigelt; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; SAg; SEA; SEAm; HLA class II; TCR; CFL; SDCC; cytotoxicity; TNF a; IFN g; mAb; PA-SEAm; anti-CD19-Fab-SEAm; B-CLL; B-NHL; AML; CML; immunotherapy; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : Bacterial superantigens (SAgs) have the property of stimulating high proportions of T cells expressing certain TCR Vβ sequences. The SAg first binds with high affinity to HLA class II molecules on the target cell and then stimulates the T cell to produce cytokines and to become cytotoxic. READ MORE

  7. 5. Factors regulating lymphocyte development and peripheral activation

    Author : Anna Makowska; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; NKT cells; TFG beta; Treg; Immunologi; serologi;

    Abstract : Peripheral tolerance is regulated by different types of regulatory T cells, including CD1-restricted T cells and CD4+CD25+ regulatory T (Treg) cells. This thesis has focused on the interactions between T cells and antigen presenting cells (APCs) and the immunregulatory function of TGF-b as two important factors regulating differentiation and activation of T cells in the periphery. READ MORE