Search for dissertations about: "TET2"

Found 2 swedish dissertations containing the word TET2.

  1. 1. Studies of epigenetic deregulation in parathyroid tumors and small intestinal neuroendocrine tumors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elham Barazeghi; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetics; 5hmC; TET1; TET2; parathyroid tumors; SI-NET; RRBS; PTPRM;

    Abstract : Deregulation of the epigenome is associated with the initiation and progression of various types of human cancers. Here we investigated the level of 5-hydroxymethylcytosine (5hmC), expression and function of TET1 and TET2, and DNA methylation in parathyroid tumors and small intestinal neuroendocrine tumors (SI-NETs). READ MORE

  2. 2. The mutational landscape and microenvironment in myelodysplastic syndromes with deletion of chromosome 5q

    University dissertation from Stockholm : Karolinska Institutet, Dept of Medicine, Huddinge

    Author : Christian Scharenberg; Karolinska Institutet.; Karolinska Institutet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Myelodysplastic Syndromes (MDS) with deletion of chromosome 5q (del(5q) are malignant bone marrow disorders characterized by macrocytic anemia, chronic transfusion dependency and an increased risk of progression to acute myeloid leukemia. A high proportion of patients with lower-risk del(5q) myelodysplastic syndromes will respond to lenalidomide treatment, but more than 40% of patients have progressed to acute leukemia five years after starting treatment. READ MORE