Search for dissertations about: "TGF DIABETIC NEPHROPATHY"
Found 4 swedish dissertations containing the words TGF DIABETIC NEPHROPATHY.
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1. Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease
Abstract : Type 1 diabetes (T1D) is etiologically considered as an autoimmune disease, where insulin-producing β-cells are damaged by autoimmune attacks. Regulatory T (Treg) cells are immune homeostasis cells. In the present thesis I aimed to investigate the role of Treg cells and other immune cells in the early development of T1D. READ MORE
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2. Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides
Abstract : The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current study we have investigated the intracellular signalling cascades activated downstream of two separate stimuli: the diabetic milieu and the cardiac glycoside, ouabain. READ MORE
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3. Functional Aspects of the Juxtaglomerular Apparatus : Control of Glomerular Filtration and Renin Release
Abstract : The juxtaglomerular apparatus (JGA) is a control unit of the kidney, that regulates glomerular filtration rate (GFR) and renin release, and hence extracellular volume and blood pressure. The tubuloglomerular feedback (TGF) mechanism is a negative feedback loop that regulates GFR. READ MORE
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4. Role of new podocyte-associated proteins in the renal ultrafiltration barrier
Abstract : Chronic kidney disease (CKD) is a major health problem and an economical burden affecting people worldwide. The main causes of CKD are diabetes and hypertension and patient numbers keep increasing. READ MORE