Search for dissertations about: "TLR4"

Showing result 1 - 5 of 85 swedish dissertations containing the word TLR4.

  2. 1. Microglial cells in Neurodegenerative Diseases. The Role of Galectin-3

    Author : Antonio Boza Serrano; Neuroinflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurosciences; microglia; Galectin-3; Alzheimer disease; Parkinson disease; innate immune system; TLR4; TREM2;

    Abstract : Today, dementia such as, Alzheimer’s disease (AD), vascular diseases and motor neurodegenerative diseases, such as Parkinson’s disease (PD), represent a major public health problem. For instance, PD affect to more than 10 million people worldwide and almost 50 million people are affected by dementia. READ MORE

  4. 2. Characterization of nontypeable Haemophilus influenzae innate interactions with human cells

    Author : Irini Lazou Ahrén; Malmö Klinisk mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; inflammation; TLR4; LBP; protein D; nontypeable Haemophilus influenzae; beta-glucan;

    Abstract : Non-typeable Haemophilus influenzae (NTHi) is a human pathogen causing diseases in the upper and lower respiratory tract. Otitis media-prone children and adults with cystic fibrosis or chronic obstructive pulmonary disease, are repeatedly infected by NTHi Research in recent years brought to light the entry and survival of NTHi in epithelial cells and macrophages. READ MORE

  5. 3. Mechanisms of microbial-host interaction during asymptomatic bacteriuria

    Author : Jenny Grönberg Hernandez; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asymptomatic bacteriuria; Urinary tract infection; Escherichia coli 83972; IRF3; TLR4; Evolution; host response; promoter polymorphisms; transcription; P fimbriae; Type 1 fimbriae;

    Abstract : Urinary tract infections (UTIs) present an interesting and relevant model for studying microbial adaptation. After establishing significant numbers, the bacteria either cause severe disease, or an asymptomatic carrier state resembling the normal flora at other mucosal sites. READ MORE

  6. 4. Immune responses to lipopolysaccharide in relation to allergic disease : a TLR4 gene polymorphism and endotoxin exposure

    Author : Anna Lundberg; Malin Fagerås Böttcher; Outi Vaarala; Marita Troye-Blomberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Background: Allergic diseases have increased during the last decades, particularly in affluent countries, possibly due to a reduced and/or altered microbial exposure during infancy. Activation of the immune system by microbes early in life is probably required for accurate maturation of the immune system and tolerance development. READ MORE

  7. 5. Role of TLR4 in Escherichia coli urinary tract infection

    Author : Patrik Samuelsson; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mykologi; virologi; mycology; Mikrobiologi; bakteriologi; serologi; transplantation; Microbiology; virology; bacteriology; Immunologi; serology; Immunology; Pathogen; Mucosa; P-fimbriae; Toll like receptor;

    Abstract : In this thesis we have used P fimbriated E. coli as a model to investigate the mechanisms of bacterial recognition and cell activation by the urinary tract (UT) epithelium. We show that Toll like receptor 4 (TLR4) is crucial for the recognition and host response to P fimbriated E. coli. READ MORE