Search for dissertations about: "TNF antagonists"
Showing result 1 - 5 of 16 swedish dissertations containing the words TNF antagonists.
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1. Treatment of arthritis with tumour necrosis factor antagonists. Clinical, immunological and biochemical aspects
Abstract : Abstract The treatment of arthritis has undergone a dramatic change since biological agents targeting specific mediators of the disease process have been introduced. Tumour necrosis factor (TNF) antagonists have been shown to reduce signs and symptoms of disease and to retard the development of tissue damage in the majority of patients. READ MORE
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2. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability
Abstract : Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. READ MORE
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3. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis
Abstract : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. READ MORE
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4. Development of molecular recognition by rational and combinatorial engineering
Abstract : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. READ MORE
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5. MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
Abstract : INTRODUCTION Stroke is a serious neurological disease which may lead to death and severe disability [1, 2]. There are two major types of stroke: ischemic and hemorrhagic stroke. READ MORE