Search for dissertations about: "TNP-470"

Found 5 swedish dissertations containing the word TNP-470.

  2. 1. Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors

    Author : Ulrika Bäckman; Rolf Christofferson; Sven Påhlman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Angiogenesis; Neuroblastoma; MYCN; VEGF; SU11657; SU5416; TNP-470; zoledronic acid; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. READ MORE

  4. 2. Angiostatic treatment of neuroblastoma

    Author : Erik Wassberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Angiogensis; Angiostatic treatment; Apoptosis; Chromogranin A; Differentiation; Neuroblastoma; 2-Methoxyestradiol; 2-Propynylestradiol; TNP-470; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : Neuroblastoma is a malignant solid tumor of childhood with a poor prognosis. The growth of solid tumors has been shown to be dependent on new blood vessel formation, i.e. angiogenesis. READ MORE

  5. 3. Angiogenesis in obesity and cancer

    Author : Ebba Bråkenhielm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adiponectin; endothelial cells; Leptin; Resveratrol; TNP-470;

    Abstract : Angiogenesis is the process of blood vessel growth from pre-existing vasculatures. In the adult, it is involved in certain physiological processes, such as in organ and tissue regeneration, wound healing, and in female reproductive cycles. READ MORE

  6. 4. Application of a New Logic to Old Drugs: Angiogenesis Inhibition in Neuroblastoma

    Author : Åsa Svensson; Rolf Christofferson; Per Kogner; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell biology; angiogenesis; neuroblastoma; CHS 828; digoxin; combination treatment; Cellbiologi; Cell biology; Cellbiologi; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Neuroblastoma is one of the most common solid cancers of early childhood. In Sweden, approximately 10-15 cases occur annually. The overall five-year neuroblastoma survival in Europe is approximately 45%. Since cancer treatment involves drugs with risks of side effects in the growing child, there is a need for more effective and less toxic drugs. READ MORE

  7. 5. Tumor lipid status and the responses to therapy in neuroblastoma : with emphasis on treatment monitoring by proton magnetic resonance spectroscopy

    Author : Magnus Lindskog; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis, the aberrant lipid and phospholipid metabolism of neuroblastoma was exploited for tumor monitoring and as target of experimental therapy. Neuroblastoma is the most common and deadly solid tumor of childhood. Since neuroblastoma cells are highly proliferative, aberrantly regulated metabolic pathways would be expected. READ MORE