Search for dissertations about: "Taxol"

Showing result 1 - 5 of 13 swedish dissertations containing the word Taxol.

  2. 1. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics

    Author : Henrik Green; Curt Peterson; Peter Söderkvist; Per Rosenberg; Håkan Melhus; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; Clinical pharmacology; Klinisk farmakologi;

    Abstract : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. READ MORE

  4. 2. A Novel Rearrangement of Allyl Benzyl Ethers and Aspects on the Glyoxylate Ene Reaction

    Author : Johan Wennerberg; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; liverwort; natural product synthesis; phenyl butyraldehydes; allyl benzyl ethers; 2-hydride migration; 1; 4-rearrangement; regio selectivity; shape selectivity; zeolite; Ene reaction; Taxol A-ring; naphthalene derivatives; dihydronaphthalenes; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes an improvement of the glyoxylate ene reaction by using siamyl glyoxaylate and a development of the novel rearrangement of allyl benzyl ethers. The glyoxylate ene reaction was used as a key reaction in a 8-step synthesis of a Taxol A-ring building block. READ MORE

  5. 3. Amino acid-catalyzed synthesis of amino acid derivatives : Application and semi-synthesis of Paclitaxel, Docetaxel and their derivatives

    Author : Pawel Dziedzic; Armando Córdova; Stephen Hanessian; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Organocatlysis; amino acids; syntesis; Taxol and Taxotere derivatives; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis deals with different applications of organocatalysis, where amino acid derivatives and small peptides are applied as catalysts. First, the development of environmentally friendly aldol reactions, carried out in aqueous media is illustrated. The corresponding β-hydroxy ketones are formed with ee´s up to 99%. READ MORE

  6. 4. High resolution genomic tools for the discovery of protein function in mammalian cells

    Author : Emily Carol Hodges; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell-based assays; overexpression; RNAi; BC2; C3F; Taxol;

    Abstract : The work described in this thesis emphasizes the development of cell-based strategies with increased throughput design that enable rapid biological discovery through direct investigation of protein function. Each of the works represented in this thesis are unified by the common premise that genetic perturbations, through loss or gain-of-function, in cell-based models may serve as an entry point for assigning biological roles to uncharacterized genes and their gene products. READ MORE

  7. 5. Design, synthesis and evaluation of spiro-bicyclo[2.2.2]octane derivatives as paclitaxel mimetics

    Author : Sophie Manner; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric baker s yeast reduction; paclitaxel; spiro; bicyclo[2.2.2]octane; paclitaxel mimetics;

    Abstract : Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. READ MORE