Search for dissertations about: "Th1 and Th2"

Showing result 1 - 5 of 155 swedish dissertations containing the words Th1 and Th2.

2. 1. Immunopathogenesis of schistosomiasis mansoni : Immunity and pathology in a primary and a secondary infection following chemotherapy in the mouse and the baboo models

   Author : Idle Omar Farah; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Baboon; BALB c mice; Chemotherapy; Cytokines; Fibrosis; Granuloma; Modulation; Pathology; Reinfection; Schistosoma mansoni; Th1; Th2; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Medicine; medicin;

   Abstract : This thesis describes a series of experiments aimed at elucidating the mechanisms ofimmunity and pathology elicited by both a primary infection and a reinfection exposure toSchistosoma mansoni following chemotherapy. The effects of a single large cercarial doseand a cumulatively equivalent dose, administered as multiple small doses are compared. READ MORE

4. 2. Specific and nonspecific immune mechanisms in human gut : a comparative study of normal and ulcerative colitis intestine

   Author : Moorix Mo-Wai Yeung; Sten Hammarström; Marie-Louise Hammarström; Marita Troye-Blomberg; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human intestine; ulcerative colitis; lymphoid aggregates; intraepithelial lymphocytes; lamina propria lymphocytes; γδT-cells; cytokines; IL-2; carcinoembryonic antigen; biliary glycoprotein; epithelial cells; glycocalyx;

   Abstract : The intestine, with its large mucosal surface area, digests and absorbs food nutrients and maintains a beneficial microbial flora in the colon. Local protective immune responses against intestinal pathogens ensure the survival of the individual. These immune reactions are both specific and non-specific in nature. READ MORE

5. 3. Systemic sclerosis : vascular, pulmonary and immunological aspects

   Author : Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

   Abstract : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. READ MORE

6. 4. Aspects of the Pre-Diabetic Period in Type 1 Diabetes

   Author : Linda Åkerman; Rosaura Casas; Johnny Ludvigsson; Susan Wong; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Abstract : Type 1 diabetes (T1D) is an autoimmune disease characterized by insulin deficiency, due to immune-mediated destruction of beta cells. Current knowledge regarding the period preceding disease onset comes, to a large extent, from studying risk cohorts based on relatives of T1D-patients, as they have an increased disease risk. READ MORE

7. 5. Mercury-induced autoimmunity : Genetics and immunoregulation

   Author : Monika Hansson; Manuchehr Abedi-Valugerdi; Marita Troye-Blomberg; Lucette Pelletier; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mercury; autoimmunity; collagen-induced arthritis; Th1 Th2; silver; tight-skin 1 mice; Immunology; Immunologi;

   Abstract : The existence of immune self-tolerance allows the immune system to mount responses against infectious agents, but not against self-molecular constitutes. Although self-tolerance is a robust phenomenon, in some individuals as well as in experimental models, the self-tolerance breaks down and as a result, a self-destructive autoimmune disease emerges. READ MORE