Search for dissertations about: "Transit compartment model"

Found 4 swedish dissertations containing the words Transit compartment model.

2. 1. Improved pharmacometric model building techniques

   Author : Radojka Savic; Mats Karlsson; Siv Jönsson; Matt Hutmacher; Uppsala universitet; []
   Keywords : Model building; Absorption model; Transit compartment model; Nonparametric method; Extended grid method; Semiparametric; Distribution transformation; Shrinkage; Model diagnostics;

   Abstract : Pharmacometric modelling is an increasingly used method for analysing the outcome from clinical trials in drug development. The model building process is complex and involves testing, evaluating and diagnosing a range of plausible models aiming to make an adequate inference from the observed data and predictions for future studies and therapy. READ MORE

4. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

   Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

   Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

5. 3. Modelling of tolerance and rebound in normal and diseased rats

   Author : Christine Ahlström; Göteborgs universitet; []
   Keywords : feedback modelling; tolerance; rebound; pharmacokinetics; pharmacodynamics; dyslipidaemia; nicotinic acid; non-esterified fatty acids;

   Abstract : The development of rebound and tolerance is an important consideration when optimizing medical therapy, both with respect to drug dosing and adverse effects. By using quantitative approaches to study these processes, potential risks can be minimized. READ MORE

6. 4. WAVELET NOISE REDUCTION AND VASCULAR WATER TRANSPORT MODELLING : APPLICATIONS TO DIFFUSION AND PERFUSION MRI

   Author : Adnan Bibic; Lund Medicinsk strålningsfysik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral blood flow; perfusion; diffusion; arterial spin labelling; wavelets; filtering; denoising; blood-brain barrier; permeability; Fysicumarkivet A:2018:Bibic;

   Abstract : Magnetic resonance imaging (MRI) is a powerful medical imaging technique, used to detect and characterise a range of diseases and conditions. It is based on the use of a strong static magnetic field in combination with magnetic field gradients and pulsed radiofrequency electromagnetic fields to visualise various organs and structures in the body according to their morphology or function. READ MORE